(@idsociety)

AoU Research Priorities Use Cases

Using human microbiome data to improve pathogenesis and treatment of infectious diseases

Precision microbiome engineering could be applied to vaccine delivery, immunology, drug-resistant infections, and post-surgical infections. Specific research questions re pathogenesis and treatment: - What aspects of the indigenous microbiota mediate colonization resistance against C. difficile, as well as other multi-drug resistant organisms such as carbapenamase-producing gram negative bacteria and vancomycin resistant... more »

Voting

31 votes
Ideate
(@idsociety)

AoU Research Priorities Use Cases

How can AoU data be harnessed to improve infectious diseases patient care, diagnostics, vaccinolology, and drug development?

How is precision medicine as it applies to infectious diseases different than how it is considered for Oncology or other fields?

• Time-pressured setting (e.g., initiating therapy for a hospital acquired or ventilator-associated bacterial pneumonia patient)

• Microbiome vs. human genome

• Intersections with other cognitive and procedural specialties across the board

Voting

21 votes
Ideate
(@idsociety)

AoU Research Priorities Use Cases

How can AoU data be harnessed to improve infectious diseases patient care, diagnostics, vaccinolology, and drug development?

How is precision medicine as it applies to infectious diseases different than how it is considered for Oncology or other fields?

• Time-pressured setting (e.g., initiating therapy for a hospital acquired or ventilator-associated bacterial pneumonia patient)

• Microbiome vs. human genome

• Intersections with other cognitive and procedural specialties across the board

Voting

21 votes
Ideate
(@vshah92)

AoU Research Priorities Use Cases

Changes involved in the progression of T2D and development of complications is apparent at the pre-DM state or during the transi

Changes involved in the progression of T2D and development of complications is apparent at the pre-DM state or during the transition to T2D or with complications. Conducting ‘Omics’ including DNA methylation, metabolomics and microbiome studies in blood, saliva and Fecal samples allows to validate interactions of metabolites to microbiota to epigenetic regulations.

Voting

6 votes
Ideate
(@evogtmann)

AoU Research Priorities Use Cases

Are microbial tumor characteristics predictive of cancer treatment effects and survival?

Microbiota has been found in tumor tissues and these communities are often found to differ from the neighboring healthy tissue. Current studies tend to be small and from single cancer centers. We propose collecting tumor samples for microbial analysis in conjunction with cancer treatment data to evaluate microbial characteristics which predict successful treatment. Comparisons can be made to evaluate microbial compositions... more »

Voting

5 votes
Ideate
(@evogtmann)

AoU Research Priorities Use Cases

Is the human oral and fecal microbiota associated with chronic disease risk factors, such as obesity and metabolic syndrome?

The human microbiota has been found to be associated with a number of health conditions, such as obesity. However, these studies have been relatively small and from convenience samples. It is important to understand how the human microbiota impacts these chronic disease risk factors in order to prevent future disease development. We propose collecting oral and fecal samples to determine associations with many chronic... more »

Voting

28 votes
Ideate
(@agoldsteinnih1)

AoU Research Priorities Use Cases

Investigate whether ethanol consumption facilitates absorption of carcinogenic products from oral microbiome constituents.

Oral bacteria are known to have both beneficial and detrimental effects on oral health including carcinogenesis in the oral cavity. Since ethanol is a good organic solvent, oral bacterial enzymes and toxins may achieve greater exposure to the oral mucosa as a result of ethanol consumption, facilitating toxin access to intracellular processes. Subjects with different microbiome profiles and bacterial metabolites can be... more »

Voting

4 votes
Ideate
(@sjogrens.syndrome.foundation)

AoU Research Priorities Use Cases

How can we translate knowledge about the microbiome into better ways to diagnose and treat autoimmune diseases?

The scientific and medical communities are rapidly learning more about the human microbiome and the role it plays in our health, but there are still many gaps that need to be addressed. The purpose of this study would be to focus on identifying the relationship between the microbiome and a systemic disease state, helping to inform new methods for translating knowledge about the micriobiome into better, more efficient... more »

Voting

40 votes
Ideate
(@sjogrens.syndrome.foundation)

AoU Research Priorities Use Cases

How can we translate knowledge about the microbiome into better ways to diagnose and treat autoimmune diseases?

The scientific and medical communities are rapidly learning more about the human microbiome and the role it plays in our health, but there are still many gaps that need to be addressed. The purpose of this study would be to focus on identifying the relationship between the microbiome and a systemic disease state, helping to inform new methods for translating knowledge about the micriobiome into better, more efficient... more »

Voting

40 votes
Ideate
(@rborban)

AoU Research Priorities Use Cases

Can we develop a protocol to assess for Leaky Gut self help regimen to follow to heal the gut and establish a healtjy gut

1. Questionaire to assess for Leaky Gut.

2. Lab tests to assess for abnormal Intestinal flora.

3. Serum lab tests to assess for inflamation in body.

4. Dietary and nutritional supplement protocol to follow to establish healthy gut microbiome.

5. Correlate positive leaky gut diagnosis with other medical disorders present in the subject.

Voting

15 votes
Ideate
(@drirene)

AoU Research Priorities Use Cases

Could the Precision Medicine Initiative Reduce Social Inequality?

The proposed study would identify microbial communities and metabolic profiles associated with stigmatized conditions such as idiopathic malodor or mental health. Working with systemic malodor/PATM community provides unprecedented opportunities to explore biomarkers of depression, social stress, diabetes, inflammatory diseases, dental, cardiovascular, and digestive health, exposure to antibiotics, lifestyle & dietary... more »

Voting

219 votes
Ideate
(@ermueller)

AoU Research Priorities Use Cases

What is the impact of fluid intake on health?

There is a fluid intake range that is healthy. Below this level predisposes to urinary tract infections, urinary stone formation, changes in the gut and urinary micro biome, and results in generalized symptoms of well-being. Fluid intake above a healthy threshold predisposes to lower urinary tract symptoms, sleep interruptions and may affect symptoms of well-being.

Voting

48 votes
Ideate
(@nichd.allofus)

AoU Research Priorities Use Cases

What microbiome characteristics of children exposed to antibiotics and different diets influence long-term health outcomes?

Follow a subsample of all infants and children (< 3 years of age) throughout childhood to obtain the following serial assessments: blood tests, medication history, neonatal, infant and childhood health outcomes; physical measurements and laboratory microbiologic evaluations of oral, skin and vaginal specimens. Assessments and measures would be used along with health outcomes to determine associations and develop predictive... more »

Voting

153 votes
Ideate
(@nichd.allofus)

AoU Research Priorities Use Cases

What microbiome characteristics of children exposed to antibiotics and different diets influence long-term health outcomes?

Follow a subsample of all infants and children (< 3 years of age) throughout childhood to obtain the following serial assessments: blood tests, medication history, neonatal, infant and childhood health outcomes; physical measurements and laboratory microbiologic evaluations of oral, skin and vaginal specimens. Assessments and measures would be used along with health outcomes to determine associations and develop predictive... more »

Voting

153 votes
Ideate
(@nichd.allofus)

AoU Research Priorities Use Cases

What characteristics distinguish a healthy maternal pregnancy-microbiome from one that experienced microbial perturbations?

This study will focus on a subsample of all pregnant women and follow them throughout pregnancy to obtain serial assessments and measurements, including laboratory microbiologic evaluation testing of oral, skin and vaginal specimens. Follow-up would end at delivery of the infant; serial pregnancies would be eligible to re-enroll. Assessments and measures would be used along with health outcomes to determine associations... more »

Voting

43 votes
Ideate