Showing 22 ideas for tag "microbiome"
(@sjogrens.syndrome.foundation) kudos icon +

AoU Research Priorities Use Cases

How can we translate knowledge about the microbiome into better ways to diagnose and treat autoimmune diseases?

The scientific and medical communities are rapidly learning more about the human microbiome and the role it plays in our health, but there are still many gaps that need to be addressed. The purpose of this study would be to focus on identifying the relationship between the microbiome and a systemic disease state, helping to inform new methods for translating knowledge about the micriobiome into better, more efficient... more »

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40 votes
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(@rborban) kudos icon +

AoU Research Priorities Use Cases

Can we develop a protocol to assess for Leaky Gut self help regimen to follow to heal the gut and establish a healtjy gut

1. Questionaire to assess for Leaky Gut.

2. Lab tests to assess for abnormal Intestinal flora.

3. Serum lab tests to assess for inflamation in body.

4. Dietary and nutritional supplement protocol to follow to establish healthy gut microbiome.

5. Correlate positive leaky gut diagnosis with other medical disorders present in the subject.

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15 votes
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(@drirene) kudos icon +

AoU Research Priorities Use Cases

Could the Precision Medicine Initiative Reduce Social Inequality?

The proposed study would identify microbial communities and metabolic profiles associated with stigmatized conditions such as idiopathic malodor or mental health.
Working with systemic malodor/PATM community provides unprecedented opportunities to explore biomarkers of depression, social stress, diabetes, inflammatory diseases, dental, cardiovascular, and digestive health, exposure to antibiotics, lifestyle & dietary... more »

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219 votes
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(@ermueller) kudos icon +

AoU Research Priorities Use Cases

What is the impact of fluid intake on health?

There is a fluid intake range that is healthy. Below this level predisposes to urinary tract infections, urinary stone formation, changes in the gut and urinary micro biome, and results in generalized symptoms of well-being. Fluid intake above a healthy threshold predisposes to lower urinary tract symptoms, sleep interruptions and may affect symptoms of well-being.

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48 votes
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(@nichd.allofus) kudos icon +

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What microbiome characteristics of children exposed to antibiotics and different diets influence long-term health outcomes?

Follow a subsample of all infants and children (< 3 years of age) throughout childhood to obtain the following serial assessments: blood tests, medication history, neonatal, infant and childhood health outcomes; physical measurements and laboratory microbiologic evaluations of oral, skin and vaginal specimens. Assessments and measures would be used along with health outcomes to determine associations and develop predictive... more »

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153 votes
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(@nichd.allofus) kudos icon +

AoU Research Priorities Use Cases

What characteristics distinguish a healthy maternal pregnancy-microbiome from one that experienced microbial perturbations?

This study will focus on a subsample of all pregnant women and follow them throughout pregnancy to obtain serial assessments and measurements, including laboratory microbiologic evaluation testing of oral, skin and vaginal specimens. Follow-up would end at delivery of the infant; serial pregnancies would be eligible to re-enroll. Assessments and measures would be used along with health outcomes to determine associations... more »

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43 votes
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(@nichd.allofus) kudos icon +

AoU Research Priorities Use Cases

What are the unique factors associated with early onset obesity in different ethnic and racial groups?

This study will focus on women who are pregnant when they enroll, or become pregnant during the study, in order to follow their infants from birth to 8 years of age to determine trajectories of growth over time and identify genomic and epigenomic factors related to development of obesity. Critical to obtaining this information will be the review of Electronic Health Records of providers who have the correct measuring... more »

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155 votes
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