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AoU Research Priorities Use Cases

What alternative methods of measurement for height & weight will be used in those who cannot use standard normative measures?

This study will focus on individuals who cannot be measured in a standard way for height & weight. Specification of recumbent and head circumference measurements should be added for young children. The use of alternative systems for children, adolescents, and adults for measurement of height (e.g. ulnar length, arm wingspan, or recumbent height) and measurement of weight that incorporates potential assistive devices and/or... more »

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5 votes
Ideate
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AoU Research Priorities Use Cases

What is the effect of the individual’s family and community network on health status and health behaviors?

Focusing on the entire cohort, this study seeks to define inter-relationship linkages between the person (“ego”) and other associated participants (“alters”). Previous studies identified linkages through the specification of a family roster and alternate points of contact in the consent process. The relationship data produced would be available for network analysis to determine the impact of the social network on health... more »

Voting

23 votes
Ideate
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AoU Research Priorities Use Cases

What are the genetic and environmental risk factors that contribute to the broader autism phenotype in adolescents and adults?

To study genotype-phenotype correlations, utilize measures targeting the Broader Autism Phenotype: social and communication scales (SRS), Connors Rating Scale for ADHD, ratings of depressive symptoms (PHQ-9), anxiety disorders, & adverse childhood experiences (ACEs) & traumatic life events. Children transitioning to adulthood during the study will have repeat assessment of function and mental health status at a later... more »

Voting

42 votes
Ideate
(@nichd.allofus)

AoU Research Priorities Use Cases

What are the genetic and environmental risk factors that contribute to the broader autism phenotype in adolescents and adults?

To study genotype-phenotype correlations, utilize measures targeting the Broader Autism Phenotype: social and communication scales (SRS), Connors Rating Scale for ADHD, ratings of depressive symptoms (PHQ-9), anxiety disorders, & adverse childhood experiences (ACEs) & traumatic life events. Children transitioning to adulthood during the study will have repeat assessment of function and mental health status at a later... more »

Voting

42 votes
Ideate
(@nichd.allofus)

AoU Research Priorities Use Cases

What are the long-term effects and risks of opioid use disorder during pregnancy on maternal and child health?

This study will focus on the entire cohort. The goal will be to determine the interaction of genomic, sociodemographic, physiologic and environmental factors for the mother and child impacted by Neonatal Opioid Withdrawal Syndrome (NOWS) and their impact on treatment response, treatment outcome, health outcomes for the mother, and developmental outcomes for the child.

Voting

120 votes
Ideate
(@nichd.allofus)

AoU Research Priorities Use Cases

What are the long-term effects and risks of opioid use disorder during pregnancy on maternal and child health?

This study will focus on the entire cohort. The goal will be to determine the interaction of genomic, sociodemographic, physiologic and environmental factors for the mother and child impacted by Neonatal Opioid Withdrawal Syndrome (NOWS) and their impact on treatment response, treatment outcome, health outcomes for the mother, and developmental outcomes for the child.

Voting

120 votes
Ideate
(@nichd.allofus)

AoU Research Priorities Use Cases

What genetic and environmental risk factors contribute to the development of pelvic organ prolapse (POP) as females age?

This study will focus on the entire cohort (menarche through lifespan) to collect data on general health and wellbeing as well as detailed pregnancy & delivery histories. Activity level will be monitored, specifying any straining associated with either physical activity or occupation. Genetic/epigenetic factors, such as family history of POP or connective tissue disorders will be obtained, as will data on other currently... more »

Voting

25 votes
Ideate
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AoU Research Priorities Use Cases

What microbiome characteristics of children exposed to antibiotics and different diets influence long-term health outcomes?

Follow a subsample of all infants and children (< 3 years of age) throughout childhood to obtain the following serial assessments: blood tests, medication history, neonatal, infant and childhood health outcomes; physical measurements and laboratory microbiologic evaluations of oral, skin and vaginal specimens. Assessments and measures would be used along with health outcomes to determine associations and develop predictive... more »

Voting

153 votes
Ideate
(@nichd.allofus)

AoU Research Priorities Use Cases

What microbiome characteristics of children exposed to antibiotics and different diets influence long-term health outcomes?

Follow a subsample of all infants and children (< 3 years of age) throughout childhood to obtain the following serial assessments: blood tests, medication history, neonatal, infant and childhood health outcomes; physical measurements and laboratory microbiologic evaluations of oral, skin and vaginal specimens. Assessments and measures would be used along with health outcomes to determine associations and develop predictive... more »

Voting

153 votes
Ideate
(@nichd.allofus)

AoU Research Priorities Use Cases

What characteristics distinguish a healthy maternal pregnancy-microbiome from one that experienced microbial perturbations?

This study will focus on a subsample of all pregnant women and follow them throughout pregnancy to obtain serial assessments and measurements, including laboratory microbiologic evaluation testing of oral, skin and vaginal specimens. Follow-up would end at delivery of the infant; serial pregnancies would be eligible to re-enroll. Assessments and measures would be used along with health outcomes to determine associations... more »

Voting

43 votes
Ideate
(@nichd.allofus)

AoU Research Priorities Use Cases

What characteristics distinguish a healthy maternal pregnancy-microbiome from one that experienced microbial perturbations?

This study will focus on a subsample of all pregnant women and follow them throughout pregnancy to obtain serial assessments and measurements, including laboratory microbiologic evaluation testing of oral, skin and vaginal specimens. Follow-up would end at delivery of the infant; serial pregnancies would be eligible to re-enroll. Assessments and measures would be used along with health outcomes to determine associations... more »

Voting

43 votes
Ideate
(@nichd.allofus)

AoU Research Priorities Use Cases

What risk factors predispose children to sepsis, and what interventions are most effective for prevention and treatment?

This study will focus on the entire cohort of children (infants-18 y/o) and will identify those risk factors which predispose children to sepsis. The information will be used to create more precise strategies to identify individuals at highest risk of sepsis and to implement preventive or early treatment therapies that would improve outcomes. The study will also assess the use of adjunctive immunomodulatory therapies... more »

Voting

35 votes
Ideate
(@nichd.allofus)

AoU Research Priorities Use Cases

What risk factors predispose children to sepsis, and what interventions are most effective for prevention and treatment?

This study will focus on the entire cohort of children (infants-18 y/o) and will identify those risk factors which predispose children to sepsis. The information will be used to create more precise strategies to identify individuals at highest risk of sepsis and to implement preventive or early treatment therapies that would improve outcomes. The study will also assess the use of adjunctive immunomodulatory therapies... more »

Voting

35 votes
Ideate
(@nichd.allofus)

AoU Research Priorities Use Cases

How are sleep characteristics associated with pediatric developmental conditions, disorders or chronic disease?

This study will focus on the entire cohort (infant-19 y/o) to provide health and behavior outcomes associated with sleep characteristics, including environmental and demographic factors. This information will help better define the development of sleep, help develop more precise strategies to target children with sleep characteristics predictive of poor health outcomes, and develop more precise strategies for children... more »

Voting

94 votes
Ideate
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AoU Research Priorities Use Cases

What are the unique factors associated with early onset obesity in different ethnic and racial groups?

This study will focus on women who are pregnant when they enroll, or become pregnant during the study, in order to follow their infants from birth to 8 years of age to determine trajectories of growth over time and identify genomic and epigenomic factors related to development of obesity. Critical to obtaining this information will be the review of Electronic Health Records of providers who have the correct measuring... more »

Voting

155 votes
Ideate