(@dlwn83)

AoU Research Priorities Use Cases

Opioid epidemic study: can combining ultra-low-dose naltrexone with an opioid help prevent negative psychosocial outcomes?

A randomized controlled study to determine if the combination of ultra-low-dose naltrexone with an opioid can provide better psychosocial outcomes for chronic pain patients. It would compare the results of treatment with various common opioids both alone and in combination with ultra-low-dose naltrexone. The goal is to see which treatment yields the best psychosocial outcomes and pain relief. Preliminary studies suggest... more »

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4 votes
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(@kevin0)

AoU Research Priorities Use Cases

Can widespread use of Endomorphin 1 & 2 end the opioid overdose crisis? They don't cause respiratory depression or addiction.

Endomorphine is a highly selective mu but not delta or kappa receptors which cause all the unwanted side effects of opioids. Goals - Prove Endomorphin's superiority to other opioids. Methods - Monitor pain levels, addiction through tox screens and mortality rates from overdose. Expected outcome - Endomorphin will have very low if any overdoses, tolerance build up should be minimal, alcohol addiction should be reduced,... more »

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6 votes
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(@johnbeachtx)

AoU Research Priorities Use Cases

Cytochrome P450 polymorphisms affect patient metabolism; would profiling CYP in large studies help predict patient outcomes?

Establish CYP profiling as a standard part of data collection in all large studies, especially related to pain management, immunology, cardiovascular dysfunction, pharmacology. Based upon existing research, it can be anticipated that CYP profiles and polymorphism data may partition certain studies' patient populations into groups with common outcomes (negative, positive, neutral.) Regarding the opioid crisis alone, CYP... more »

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16 votes
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(@jkasten)

AoU Research Priorities Use Cases

What risk factors predispose patients treated for pain to misuse or abuse prescription drugs?

Conduct a RCT to explore genetic and environmental risk factors associated with dose escalation leading to misuse or abuse of prescribed opioids. Use EHR and PDMP data to capture patient demographic, history, and treatment information. Goal is to determine if there are risk factors that predispose pain patients to opioid abuse.

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16 votes
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