AoU Research Priorities Use Cases

Is there a relationship between work-related injuries and opioid use (in either direction)?

Workers in certain occupations might be more likely to use opioids if their first introduction to opioids follows a workplace illness or injury. Some of those same workers may abuse the drugs due to stressors at work. Also, workers using opioids might be more likely to injure themselves at work if they are less sensitive to pain and might be slower to react or less likely to notice dangerous workplace conditions. AoU... more »

Voting

1 vote
Ideate
(@pradeepsuri1)

AoU Research Priorities Use Cases

Are there clinically meaningful subgroups of low back pain (LBP) defined by lifestyle, clinical features, and/or genomics?

LBP is the #1 cause of years lived with disability worldwide (GBD 2016), yet little is known about its underlying mechanisms. In standard clinical care, people with very different presentations of LBP are treated the same. Longitudinal survey items related to LBP, and data collection already planned by AoU (surveys + physical measurements + EHR + genomics) can be used to identify meaningful LBP subgroups that are connected... more »

Voting

3 votes
Ideate
(@alex.breskin)

AoU Research Priorities Use Cases

How has the opioid abuse epidemic impacted hepatitis C incidence?

Hepatitis C virus (HCV) is often transmitted through the use of shared injection drug paraphernalia. With the rise in opioid abuse, it is reasonable to expect a corresponding rise in HCV incidence. Current treatments can effectively cure HCV, making it more important than ever to identify those most at risk. Using data from this cohort, we can determine the current incidence of HCV and its association with opioid use,... more »

Voting

3 votes
Ideate
(@alex.breskin)

AoU Research Priorities Use Cases

How has the opioid abuse epidemic impacted hepatitis C incidence?

Hepatitis C virus (HCV) is often transmitted through the use of shared injection drug paraphernalia. With the rise in opioid abuse, it is reasonable to expect a corresponding rise in HCV incidence. Current treatments can effectively cure HCV, making it more important than ever to identify those most at risk. Using data from this cohort, we can determine the current incidence of HCV and its association with opioid use,... more »

Voting

3 votes
Ideate
(@kevin0)

AoU Research Priorities Use Cases

Can widespread use of Endomorphin 1 & 2 end the opioid overdose crisis? They don't cause respiratory depression or addiction.

Endomorphine is a highly selective mu but not delta or kappa receptors which cause all the unwanted side effects of opioids. Goals - Prove Endomorphin's superiority to other opioids. Methods - Monitor pain levels, addiction through tox screens and mortality rates from overdose. Expected outcome - Endomorphin will have very low if any overdoses, tolerance build up should be minimal, alcohol addiction should be reduced,... more »

Voting

6 votes
Ideate
(@kcroes101)

AoU Research Priorities Use Cases

Is Mitragyna speciosa (kratom) effective in managing chronic pain?

A small randomized, double-blind, controlled clinical trial is the gold standard for establishing efficacy. The current regulatory status of kratom and access to purified extract may be a problem. Anecdotal evidence, however, would seem to justify an attempt. Access in some jurisdictions may not be a problem, and the promise of efficacy to alleviate chronic pain versus its supposed side-effect profile weighs in favor... more »

Voting

4 votes
Ideate
(@nichd.allofus)

AoU Research Priorities Use Cases

What are the long-term effects and risks of opioid use disorder during pregnancy on maternal and child health?

This study will focus on the entire cohort. The goal will be to determine the interaction of genomic, sociodemographic, physiologic and environmental factors for the mother and child impacted by Neonatal Opioid Withdrawal Syndrome (NOWS) and their impact on treatment response, treatment outcome, health outcomes for the mother, and developmental outcomes for the child.

Voting

120 votes
Ideate
(@nichd.allofus)

AoU Research Priorities Use Cases

What are the long-term effects and risks of opioid use disorder during pregnancy on maternal and child health?

This study will focus on the entire cohort. The goal will be to determine the interaction of genomic, sociodemographic, physiologic and environmental factors for the mother and child impacted by Neonatal Opioid Withdrawal Syndrome (NOWS) and their impact on treatment response, treatment outcome, health outcomes for the mother, and developmental outcomes for the child.

Voting

120 votes
Ideate