(@sunwoo)

AoU Research Priorities Use Cases

Understand the rising incidence and biology of oral cancer in younger women who lack the typical risk factors.

There is an increasing incidence of oral cancer in younger patients who lack typical risk factors like smoking and alcohol use. While most head and neck squamous cell carcinoma is male dominated, this "atypical" oral cancer seems to be equally distributed between males and females. Environmental factors (e.g. diet, medications, oral microbiome, etc.) and genetic/epigenetic factors should be studied in this atypical cohort... more »

Voting

6 votes
Ideate
(@jatkinso)

AoU Research Priorities Use Cases

What genetic factors are associated with oral cancer (OC) and oropharyngeal cancer (OPC)?

Tobacco and alcohol use and persistent oral infection with human papillomavirus (HPV) are risk factors for oral cancer (OC) and oropharyngeal cancer (OPC). CDC estimates that approximately 60% of OPC cases in the United States are caused by HPV types 16/18. Previous studies (GWAS) suggest genetic factors are associated with an increased risk of developing HPV-related OPCs. Assessing genetic factors in a large population... more »

Voting

42 votes
Ideate