AoU Research Priorities Use Cases

Can the recycling of influenza viruses explain changes in phenotypes of CHD cases?

I proposed that the 1950s-60s CHD deaths were associated with H1-H2 Influenza A re-infectiosn of H3 Influenza primed individuals (born around 1890). After 1968, when the H3 influenza virus returned, high serum cholesterol CHD cases declined and a second atherogenic phenotype emerged (H3 re-infection of H1-primed cohorts born after 1900 and more after 1918?). Would CHD mortality with high serum cholesterol levels increase... more »

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AoU Research Priorities Use Cases

Which formulation of newer generation oral contraceptives influence cancer risk?

Oral contraceptive (OC) use is associated with decreased risks of several cancers and current use increases risk for breast cancer. Most studies are limited to women who used early generation OCs—which contained higher estrogen concentrations and androgenic progestins compared to drugs used today. Research suggests that newer drugs are still associated with early breast cancer risk, however the influence on other cancers... more »

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