(@rjguzman)

AoU Research Priorities Use Cases

Contribution of genetic, environmental, and dietary factors to peripheral atherosclerosis

Peripheral artery disease (PAD) affects about 13% of the population over 50 years and it is an important cause of morbidity and mortality. The ankle brachial index (ABI) is an inexpensive and non-invasive test used to screen for PAD, and an abnormal value is associated with increased cardiovascular events. Adding the collection of serial ABIs to the All of US database will allow for numerous future studies aimed at defining ...more »

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(@tlzjones)

AoU Research Priorities Use Cases

Do specific diabetes drugs increase the risk of peripheral artery disease, a diabetic foot ulcer or an amputation?

A major advance in diabetes treatment is the finding that specific glucose-lowering drugs reduce the risk of cardiovascular disease. The results were tempered by the increased risk of amputations for the groups that received the SGLT2 inhibitor, canagliflozin. The generalizability of this finding is unknown. An understanding of the association of specific diabetes drugs with lower extremity complications will allow ...more »

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(@tlzjones)

AoU Research Priorities Use Cases

Do specific diabetes drugs increase the risk of peripheral artery disease, a diabetic foot ulcer or an amputation?

A major advance in diabetes treatment is the finding that specific glucose-lowering drugs reduce the risk of cardiovascular disease. The results were tempered by the increased risk of amputations for the groups that received the SGLT2 inhibitor, canagliflozin. The generalizability of this finding is unknown. An understanding of the association of specific diabetes drugs with lower extremity complications will allow ...more »

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10 votes
Ideate