(@pgreen00)

AoU Research Priorities Use Cases

Do systemic therapies used for cure or control of diseases like cancer, HIV, or diabetes alter aging phenotypes?

Clinical evidence suggests that cancer survivors, people living with HIV/AIDS, and diabetics may age prematurely from treatment toxicity. The All of Us study could be used to study these observatons over time by comparing aging trajectories and risk factors for individuals with and without systemic therapy use and investigate the mechanisms that cause alterations in the rate or way individuals age.

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2 votes
Ideate
(@noemie.elhadad)

AoU Research Priorities Use Cases

What are the genetic, epigenetic, and environmental factors of endometriosis, and how can they help us identify its subtypes?

Endometriosis is a systemic condition with a heavy burden on patients. It is estimated that 10% of women in reproductive age have endometriosis, but its etiology is still unknown. While it is accepted that endometriosis is a heterogeneous condition, what the exact subtypes of the disease are is still an open question.

Voting

144 votes
Ideate
(@noemie.elhadad)

AoU Research Priorities Use Cases

What are the genetic, epigenetic, and environmental factors of endometriosis, and how can they help us identify its subtypes?

Endometriosis is a systemic condition with a heavy burden on patients. It is estimated that 10% of women in reproductive age have endometriosis, but its etiology is still unknown. While it is accepted that endometriosis is a heterogeneous condition, what the exact subtypes of the disease are is still an open question.

Voting

144 votes
Ideate
(@nichd.allofus)

AoU Research Priorities Use Cases

What are the genetic and environmental risk factors that contribute to the broader autism phenotype in adolescents and adults?

To study genotype-phenotype correlations, utilize measures targeting the Broader Autism Phenotype: social and communication scales (SRS), Connors Rating Scale for ADHD, ratings of depressive symptoms (PHQ-9), anxiety disorders, & adverse childhood experiences (ACEs) & traumatic life events. Children transitioning to adulthood during the study will have repeat assessment of function and mental health status at a later ...more »

Voting

42 votes
Ideate
(@nichd.allofus)

AoU Research Priorities Use Cases

What are the genetic and environmental risk factors that contribute to the broader autism phenotype in adolescents and adults?

To study genotype-phenotype correlations, utilize measures targeting the Broader Autism Phenotype: social and communication scales (SRS), Connors Rating Scale for ADHD, ratings of depressive symptoms (PHQ-9), anxiety disorders, & adverse childhood experiences (ACEs) & traumatic life events. Children transitioning to adulthood during the study will have repeat assessment of function and mental health status at a later ...more »

Voting

42 votes
Ideate