(@mgough)

AoU Research Priorities Use Cases

How are body fat and activity level related to pregnancy outcomes in normal or high BMI athletes with normal ovulatory function?

The goal would be to examine how body fat, pre-pregnancy, and activity levels before and during pregnancy were related to pregnancy outcomes (e.g., miscarriage, full-term, low birthweight, etc.) in athletes with a normal or high BMI and normal ovulatory function; prior studies focus solely on BMI, which is often an inaccurate measure for athletes. All of Us should collect data on body fat preconception, physical activity... more »

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0 votes
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AoU Research Priorities Use Cases

AoU’s sample/measures uniquely allow for modeling high-burden disease pathways specified by the biopsychosocial ecological model

Biological, psychological & social domains interact at multiple levels (genes, human & environment microbiomes, stress, behavior, broad SES & environment) outlined by the biopsychosocial ecological model (BPSEM). The BPSEM specifies pathways aligned with the AoU pillars of biology, lifestyle, & environment. Simultaneous examination of the interacting domains and levels of the BPSEM is now computationally possible and... more »

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1 vote
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(@charles.matthews)

AoU Research Priorities Use Cases

Does physical activity done at an intensity lower than currently recommended reduce the risk of developing cancer?

We propose to investigate risk of developing cancer in a cohort of 100,000 AoU participants using NCIs Activities Completed over Time in 24-hours (ACT24) recall system (doi.org/10.1249/MSS.0000000000001428), and research grade accelerometers. Cases of incident cancer will be captured via linkage to state cancer registries.

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2 votes
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(@gerhild.ullmann)

AoU Research Priorities Use Cases

What are the health benefits of mind-body exercises such as Feldenkrais, tai chi, yoga etc.?

Health benefits of mind-body exercises are 'under-researched' compared to health benefits of aerobic exercises. Many people do not meet the current physical activity recommendations for maintaining health, in particular older adults and individuals with chronic health issues. Thus, it is of high importance to facilitate the potential health effects of mind-body exercises. Funding for well-designed randomized controlled... more »

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1 vote
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(@troianor)

AoU Research Priorities Use Cases

How are sleep, sedentary behavior and physical activity related to one another, and interactively, related to health?

Sleep (quantity, quality, timing), sedentary behavior, and physical activity of various intensities, affect each other and many health outcomes. Health conditions affect individuals’ sleep and activity patterns. Capturing 24-hour device data repeatedly will allow exploration of multiple hypotheses about sleep, sedentary behavior, physical activity and health. Longitudinal data will allow exploration of causality in both... more »

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27 votes
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(@troianor)

AoU Research Priorities Use Cases

How are sleep, sedentary behavior and physical activity related to one another, and interactively, related to health?

Sleep (quantity, quality, timing), sedentary behavior, and physical activity of various intensities, affect each other and many health outcomes. Health conditions affect individuals’ sleep and activity patterns. Capturing 24-hour device data repeatedly will allow exploration of multiple hypotheses about sleep, sedentary behavior, physical activity and health. Longitudinal data will allow exploration of causality in both... more »

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27 votes
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(@ryan.crews)

AoU Research Priorities Use Cases

What role do the pathomechanics of physical activity play in the formation and healing of diabetic foot ulcers?

Although the presence of a relationship between physical activity and diabetic foot ulcers is widely accepted, there is limited understanding of this relationship. Most studies to date have included sample sizes less than 100 participants and monitored physical activity for less than 6 months (often for only a period of several weeks). This prospective longitudinal study will evaluate the association of physical activity... more »

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8 votes
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(@ryan.crews)

AoU Research Priorities Use Cases

What role do the pathomechanics of physical activity play in the formation and healing of diabetic foot ulcers?

Although the presence of a relationship between physical activity and diabetic foot ulcers is widely accepted, there is limited understanding of this relationship. Most studies to date have included sample sizes less than 100 participants and monitored physical activity for less than 6 months (often for only a period of several weeks). This prospective longitudinal study will evaluate the association of physical activity... more »

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8 votes
Ideate

AoU Research Priorities Use Cases

What is the overall role of sports, which promote physical activity but can also contribute to injuries, in America’s health?

Sports play a unique role as a platform for physical activity, but can also increase the risk of injury. All of Us offers an opportunity to identify health benefits and risks of sports by population segment, sport, and level of play. A resulting "sports prescription for health" could be a powerful leap forward in improving health. Methods could include data on sports injuries, wearable technology, validated self-reports,... more »

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81 votes
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(@mnulam)

AoU Research Priorities Use Cases

What are the social, biological and behavioral factors that influence fatigue in adults and children?

Fatigue is commonly reported as prodromal to acute and chronic illness. At this point, we do not understand the etiology of fatigue; it is often confused with sleepiness. Longitudinal assessments of self-reported symptoms (fatigue, sleep, pain, depression), comorbid conditions, physical activity, and biomarkers will be collected monthly over 1 year to allow us to assess potential temporal effects of fatigue on daytime... more »

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26 votes
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(@mnulam)

AoU Research Priorities Use Cases

What are the social, biological and behavioral factors that influence fatigue in adults and children?

Fatigue is commonly reported as prodromal to acute and chronic illness. At this point, we do not understand the etiology of fatigue; it is often confused with sleepiness. Longitudinal assessments of self-reported symptoms (fatigue, sleep, pain, depression), comorbid conditions, physical activity, and biomarkers will be collected monthly over 1 year to allow us to assess potential temporal effects of fatigue on daytime... more »

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26 votes
Ideate

AoU Research Priorities Use Cases

What active and healthy lifestyle interventions will most effectively reduce health disparities and increase health equity?

Intentionally aim to ensure that All of Us insights extend to everyone, particularly regarding lifestyles and improved health for population segments of need and opportunity. Methods could include data collection through wearable technology, validated self-reports, comparative effectiveness data, medical reimbursement, predictive analytics, and the unique insights from All of Us. ACSM applauds this pathway to health innovation.... more »

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136 votes
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AoU Research Priorities Use Cases

What is the comparative and independent effectiveness of healthy lifestyle choices in preventing and treating diseases?

Determine the lifestyle strategies and interventions that produce the most gains in prevention and treatment of diseases in a comparative and complementary context with pharmaceutical, surgical, and other approaches. Methods could include data collection through wearable technology, validated self-reports, comparative effectiveness data, medical reimbursement, predictive analytics, and the unique insights from All of... more »

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139 votes
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