Enroll sufficient numbers of pregnant women and their offspring to study the causes of pregnancy complications including preeclampsia, preterm birth, still birth, intrauterine growth restriction. Target high-risk pregnancies such as obesity, preexisting diabetes, and gestational diabetes. Follow up long term effect and study genetic contributions in a family-based approach. Obtain maternal samples and placentas for possible... more »
Preeclampsia/HELLP syndrome can be caused by many different underlying conditions. If we can determine who would be at risk (either the individual women and/or couples together), perhaps the disease can be prevented by testing their embryos before implantation (IVF), or by having women at risk take Aspirin starting early in their pregnancy.
2 possible designs: 1) Enroll women diagnosed with preeclampsia (PEC) during current pregnancy and collect data (phenotype & biomarkers), follow up prospectively until cardiovascular events (acute coronary events, strokes, including cardiac surgery) 2) Ambidirectional design: enroll women with a PEC history now having cardiac surgery/cardiopulmonary bypass (CPB); collect biomarkers & clinical outcomes (phenotype after... more »