Showing 5 ideas for tag "randomized-controlled-trial"
(@ekarlson) kudos icon +

AoU Research Priorities Use Cases

Can we personalize prevention of rheumatoid arthritis?

Modifiable risk factors interact with genes to predict rheumatoid arthritis (RA). Antibodies can be detected in pre-RA, up to 10 years before symptoms.
Goal: Conduct RCT to reduce RA risk factors and delay/prevent RA onset
Methods.Find high risk subjects (+CCP, high polygenetic risk score), monitor for early sx (mHealth), conduct RCT based on motivational interviewing/health coaching vs. basic info intervention to modify... more »

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1 vote
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(@lisa.signorello) kudos icon +

AoU Research Priorities Use Cases

Would the addition of non-selective beta-blockers to cancer therapy result in better survival?

Animal models are compelling that activating the beta-adrenergic pathway (via stress) results in tumor growth and metastasis. Beta-blockers blunt this effect in animals. All of Us could design a randomized intervention trial to test this potential benefit in humans. An observational approach could also be taken with careful attention to pharmacoepi principles and biases such as confounding by indication.

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1 vote
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(@scpoole748) kudos icon +

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Does regular exercise help to reduce/eliminate anxiety?

Regular exercise prevents and improves health issues ranging from physical, mental, and emotional. I would like to conduct a RCT over the course of a year for both males and females ranging from ages 20-35 to test how regular exercise affects an individual's level of anxiety. There will be two groups, one that exercises regularly (experimental) while the other does not (control). A questionnaire will occur twice during... more »

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16 votes
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(@oracore) kudos icon +

AoU Research Priorities Use Cases

how to make RCT more efficient

All of US data source could be use to identify cohorts of individuals with key data already in the system that would be eligible to specific randomized control trial focused on treatment or prevention of certain rheumatic diseases. Such approach could substantially reduce the time required to fully enroll into clinical trials and also potentially reduce costs related to some specimen collection

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9 votes
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