Modifiable risk factors interact with genes to predict rheumatoid arthritis (RA). Antibodies can be detected in pre-RA, up to 10 years before symptoms. Goal: Conduct RCT to reduce RA risk factors and delay/prevent RA onset Methods.Find high risk subjects (+CCP, high polygenetic risk score), monitor for early sx (mHealth), conduct RCT based on motivational interviewing/health coaching vs. basic info intervention to modify... more »
Randomized trials could be set within All of Us to test these interventions at specific research sites.
Animal models are compelling that activating the beta-adrenergic pathway (via stress) results in tumor growth and metastasis. Beta-blockers blunt this effect in animals. All of Us could design a randomized intervention trial to test this potential benefit in humans. An observational approach could also be taken with careful attention to pharmacoepi principles and biases such as confounding by indication.
Regular exercise prevents and improves health issues ranging from physical, mental, and emotional. I would like to conduct a RCT over the course of a year for both males and females ranging from ages 20-35 to test how regular exercise affects an individual's level of anxiety. There will be two groups, one that exercises regularly (experimental) while the other does not (control). A questionnaire will occur twice during... more »
All of US data source could be use to identify cohorts of individuals with key data already in the system that would be eligible to specific randomized control trial focused on treatment or prevention of certain rheumatic diseases. Such approach could substantially reduce the time required to fully enroll into clinical trials and also potentially reduce costs related to some specimen collection