(@drirene)

AoU Research Priorities Use Cases

How can "All of Us" researchers collaborate to address differences and unique patterns of every individual?

Each of Us is Unique, All of Us should work together. Some diseases are generously funded because advocacy groups have powerful lobbying arms. Every individual affected could potentially contribute valuable data to different medical subspecialities. We should not box people in ICD codes, but use a narrative-based approach, stop dismissing patients' observations and patterns of limited significance - as it could lead to... more »

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17 votes
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(@jodyetheloner)

AoU Research Priorities Use Cases

Can you find a cure for tmau ( how to fix the FMO3 enzyme in our digestive system)

I have no clue how I would study it to be completely honest... But I have horrible body odor and terrible bad breath because of Trimethylaminuria (tmau). It is caused by a deficiency of flavin monooxygenase 3 (FMO3) secondary to mutations in the FMO3 gene. Please help me and others with this problem.

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10 votes
Ideate
(@anon13)

AoU Research Priorities Use Cases

Does congenital sarcosinemia reduce the risk of depression?

Congenital sarcosinemia is a rare metabolic condition characterized by elevated levels of sarcosine in the blood and bodily fluids caused by an enzyme defect. It appears to be essentially harmless. Sarcosine has recently shown promise as an atypical antidepressant with no apparent side effects and a higher rate of efficacy than citalopram. A simple study would involve using a database of known sarcosinemia patients,... more »

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4 votes
Ideate
(@drirene)

AoU Research Priorities Use Cases

Could the Precision Medicine Initiative Reduce Social Inequality?

The proposed study would identify microbial communities and metabolic profiles associated with stigmatized conditions such as idiopathic malodor or mental health. Working with systemic malodor/PATM community provides unprecedented opportunities to explore biomarkers of depression, social stress, diabetes, inflammatory diseases, dental, cardiovascular, and digestive health, exposure to antibiotics, lifestyle & dietary... more »

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219 votes
Ideate
(@eric.sid)

AoU Research Priorities Use Cases

What genetic markers can lead to early diagnosis of late-onset rare diseases (Huntington, Crohn, CMT, ALS, etc.)?

Most rare diseases, defined as those affecting fewer than 200,000 people, are genetic disorders with signs observable at birth or in childhood. However, a number have adult-onsets, such as Crohn, Charcot-Marie-Tooth, ALS or thyroid cancer. Of this subset, many have not been linked to a single genetic mutation or origin and similarly, do not have a usable biomarker for early diagnosis. Are there any genetic markers that... more »

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22 votes
Ideate