(@nhgri.divisionofgenomescience)

AoU Research Priorities Use Cases

What happens to people before and as they come down with a disease? How do high-risk people who don't get the disease differ?

We can identify people who are at high risk for many diseases. However, not all high-risk people develop the disease. This study would follow people in high-risk groups longitudinally and identify specific genomic, physiological, clinical, and exposure factors that are either predictive or protective of transition to disease. This should focus on a diverse set of people (ethnicity, gender/sex, age, SES, rural/urban,... more »

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1 vote
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(@nhgri.divisionofgenomescience)

AoU Research Priorities Use Cases

What happens to people before and as they come down with a disease? How do high-risk people who don't get the disease differ?

We can identify people who are at high risk for many diseases. However, not all high-risk people develop the disease. This study would follow people in high-risk groups longitudinally and identify specific genomic, physiological, clinical, and exposure factors that are either predictive or protective of transition to disease. This should focus on a diverse set of people (ethnicity, gender/sex, age, SES, rural/urban,... more »

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1 vote
Ideate
(@elrconsultantllc)

AoU Research Priorities Use Cases

An investigation of the resiliency of urban community residents and inclusion in longitudinal research

The purpose of this study is to understand reasons for minimal participation of urban community residents in longitudinal research. The study will also explore expectations of urban community residents as a result of participating in longitudinal research. The study will use qualitative focus group approach of urban community residents in the Midwest.

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3 votes
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(@ginawei)

AoU Research Priorities Use Cases

Why are some people with multiple cardiovascular risk factors resilient against developing cardiovascular diseases?

People who smoke or have hypertension, diabetes, and hyperlipidemia are at increased risk of developing cardiovascular diseases (CVD). However, not all do, and it would be interesting to identify those with CVD risk factors but remain free of CVD. Studying these people phenotypically, genomically, environmentally, and molecularly (via -omics) could provide great insight into novel mechanisms by which new treatments... more »

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13 votes
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(@ginawei)

AoU Research Priorities Use Cases

Why are some people with multiple cardiovascular risk factors resilient against developing cardiovascular diseases?

People who smoke or have hypertension, diabetes, and hyperlipidemia are at increased risk of developing cardiovascular diseases (CVD). However, not all do, and it would be interesting to identify those with CVD risk factors but remain free of CVD. Studying these people phenotypically, genomically, environmentally, and molecularly (via -omics) could provide great insight into novel mechanisms by which new treatments... more »

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13 votes
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(@kleinwm)

AoU Research Priorities Use Cases

Are threat management resources predictive of long-term resilience, recovery from stressful events, and higher quality of life

Measure threat management resources (self-affirmation, optimism, self-compassion, social connections) early in study and then follow up to see how well these resources predict important health outcomes prospectively. Simple prospective design.

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8 votes
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(@nfschor)

AoU Research Priorities Use Cases

Are there patient characteristics that predict resilience to and coping strategies and treatments chosen for recurrent pain?

Identify subsets of All of Us participants with chronic pain of various types. Administer questionnaire that asks in general about coping mechanisms, self-perceived pain tolerance, interference of pain disorder with function, child and adult exposures to adverse life experiences, history of depression/PTSD, drivers of decision of whether or not to treat an episode of pain, use of pharmacological therapies, use of non-pharmacological... more »

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59 votes
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