(@svogelstein)

AoU Research Priorities Use Cases

What etiology factors contribute to the onset of seizures in late adulthood?

The incidence of seizures increases after the age of 50 years. With the increased life expectancy, seizures in older adults represents an emerging and important public health concern. Although cerebrovascular disease contributes to some cases, the etiology of these seizures in most patients is large known. Metabolic factors are likely to contribute to risk in some patients as diet changes can reduce the frequency of seizures... more »

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AoU Research Priorities Use Cases

What are the risk factors (genetic, environmental, other biological) for developing epilepsy later in life?

Initial data (e.g., demographic) and data that are noted routinely as a part of healthcare maintenance (e.g., anthropomorphic factors, blood pressure, cholesterol, serum creatinine, etc.) could be collected longitudinally and then evaluated in terms of onset of epilepsy later in life. Justification: as the US population ages, the incidence and prevalence of epilepsy is expected to increase, given the association of epilepsy... more »

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12 votes
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AoU Research Priorities Use Cases

What are the risk factors (genetic, environmental, other biological) for developing epilepsy later in life?

Initial data (e.g., demographic) and data that are noted routinely as a part of healthcare maintenance (e.g., anthropomorphic factors, blood pressure, cholesterol, serum creatinine, etc.) could be collected longitudinally and then evaluated in terms of onset of epilepsy later in life. Justification: as the US population ages, the incidence and prevalence of epilepsy is expected to increase, given the association of epilepsy... more »

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12 votes
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AoU Research Priorities Use Cases

Do febrile seizures in childhood represent a risk factor for dementia in later life?

Longitudinal study with cases identified in childhood (typically, before 5-6 years of age) with the presence of febrile seizures, followed over time for the diagnosis of dementia (including mild cognitive impairment). Genetic data and viral serolgies also should be collected to identify causal/association data. Justification: febrile seizures occur in 3-5% of the US population (i.e., most common type of seizure). Changes... more »

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13 votes
Ideate

AoU Research Priorities Use Cases

Do febrile seizures in childhood represent a risk factor for dementia in later life?

Longitudinal study with cases identified in childhood (typically, before 5-6 years of age) with the presence of febrile seizures, followed over time for the diagnosis of dementia (including mild cognitive impairment). Genetic data and viral serolgies also should be collected to identify causal/association data. Justification: febrile seizures occur in 3-5% of the US population (i.e., most common type of seizure). Changes... more »

Voting

13 votes
Ideate