(@selfemail2004)

AoU Research Priorities Use Cases

Evaluate the impact of circadian clock and sleep on health and diseases prevention, progression, and treatment across lifespan

Circadian clock and/or sleep disruptions have been suggested associated with health and disease outcome. A systematic longitudinal follow up over lifespan is needed to understand the underlining mechanisms. All of Us project could provide such opportunity to evaluate the dynamic relationships of circadian clock and sleep with other multi-level factors, such as, lifestyle (diet, exercise and mental health) and behavior,... more »

Voting

0 votes
Ideate
(@jmulling)

AoU Research Priorities Use Cases

What biomarker (or array) is associated with the restorative-non-restorative sleep continuum?

Sleep participates in regulation of biological systems that support health. Sleep is experienced as restorative; and non-restorative sleep is associated with debilitating fatigue, experienced in many medical conditions. Questions are needed to assess subjective restorative quality of sleep (in the last months) together with questions about mental and physical health, sleep continuity, quality, duration and circadian timing.... more »

Voting

4 votes
Ideate
(@troianor)

AoU Research Priorities Use Cases

How are sleep, sedentary behavior and physical activity related to one another, and interactively, related to health?

Sleep (quantity, quality, timing), sedentary behavior, and physical activity of various intensities, affect each other and many health outcomes. Health conditions affect individuals’ sleep and activity patterns. Capturing 24-hour device data repeatedly will allow exploration of multiple hypotheses about sleep, sedentary behavior, physical activity and health. Longitudinal data will allow exploration of causality in both... more »

Voting

27 votes
Ideate
(@pfuller)

AoU Research Priorities Use Cases

Wearables for capturing sleep and circadian information across day/night and long-term.

Wearables that can capture sleep and circadian information-across the day/night and over time--should be included. Activity monitors, EEG, ECG and Oximetry measurement are increasingly accessible with miniaturization of technology. Consumer interest in many of these devices has accelerated development and driven costs down. Analysis of these data-perhaps using open-platforms- hold promise for deriving quantitative measurements... more »

Voting

84 votes
Ideate
(@pfuller)

AoU Research Priorities Use Cases

Wearables for capturing sleep and circadian information across day/night and long-term.

Wearables that can capture sleep and circadian information-across the day/night and over time--should be included. Activity monitors, EEG, ECG and Oximetry measurement are increasingly accessible with miniaturization of technology. Consumer interest in many of these devices has accelerated development and driven costs down. Analysis of these data-perhaps using open-platforms- hold promise for deriving quantitative measurements... more »

Voting

84 votes
Ideate
(@pfuller)

AoU Research Priorities Use Cases

Characterize the bases for the circadian timing, duration and and quality of sleep and vulnerability to develop sleep disorders

Study would seek to characterize the etiological bases, including genetic, socio-cultural and environmental, for the circadian timing, duration and quality of sleep and vulnerability to develop sleep disorders.

Voting

76 votes
Ideate
(@ataylor)

AoU Research Priorities Use Cases

What are the future outcomes for people who present with REM sleep behavior disorder (physically acting out dreams while asleep)

REM sleep behaviour (RBD) can precede subsequent Lewy body disease by many years/decades. Thus RBD could be a potent prodromal biomarker of future disease and allow for identification of an ideal target population for disease modifying treatment. In depth assessment of sleep behaviours in midlife as measured using participant survey complimented by wearable devices technology could provide unparalleled information in... more »

Voting

16 votes
Ideate
(@arianasmith)

AoU Research Priorities Use Cases

Do self-reported Nocturia episodes correlate with actual nighttime visits to the toilet; what is the natural history of nocturia

Nocturia is highly prevalent and has significant impact on quality of life. Therapeutic interventions often reduce nocturia episodes by less than one episode per night and rely on self-report data to quantify efficacy. This study will identify a cohort with nocturia and compare self-reported nocturia to actual nighttime visits to the toilet as recorded by wearable technology; and follow over time. We hypothesize that... more »

Voting

21 votes
Ideate