Showing 3 ideas for tag "sub-phenotype"
(@ginawei) kudos icon +

AoU Research Priorities Use Cases

Develop more accurate and clinically relevant sub-classification/phenotyping of heart failure

Heart failure (HF), though relatively common in U.S. adults, can be thought of as a syndrome with many subtypes that require different treatments. All of Us provides a rich platform on which to collect more data (e.g., novel biomarkers and imaging studies) on HF patients. This, coupled with AoU’s existing rich genomics, behavioral, and clinical data, can be analyzed to refine the phenotyping and sub-classification of... more »

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(@noemie.elhadad) kudos icon +

AoU Research Priorities Use Cases

What are the genetic, epigenetic, and environmental factors of endometriosis, and how can they help us identify its subtypes?

Endometriosis is a systemic condition with a heavy burden on patients. It is estimated that 10% of women in reproductive age have endometriosis, but its etiology is still unknown. While it is accepted that endometriosis is a heterogeneous condition, what the exact subtypes of the disease are is still an open question.

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(@nkeshava) kudos icon +

AoU Research Priorities Use Cases

Can machine learning algorithms reliably identify distinct sub-populations and sub-phenotypes in a specific disease cohort?

Identify a cohort with a specific medical condition, intervention, and outcome and use heterogeneous patient measurements. Using a novel, soon-to-be-published machine learning platform that performs "X-rays" of cohorts, discover distinct sub-populations, their sub-phenotypes, and different outcome rates. The ability to discover distinct sub-populations characterized across many modalities would greatly advance the... more »

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14 votes
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