(@lisa.signorello)

AoU Research Priorities Use Cases

Would the addition of non-selective beta-blockers to cancer therapy result in better survival?

Animal models are compelling that activating the beta-adrenergic pathway (via stress) results in tumor growth and metastasis. Beta-blockers blunt this effect in animals. All of Us could design a randomized intervention trial to test this potential benefit in humans. An observational approach could also be taken with careful attention to pharmacoepi principles and biases such as confounding by indication.

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1 vote
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(@lisa.signorello)

AoU Research Priorities Use Cases

Does psychosocial stress influence time to cancer recurrence or cancer survival for various tumor types?

In animal models, stress is a trigger for tumor growth and metastasis, yet we have not adequately addressed this question in human cancer patients or survivors.

All of Us could longitudinally assess the biological experience of psychosocial stress (via biomarker or wearable technology) at specified times in the cancer survivorship period, and conduct an analysis of time to recurrence or time to death.

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2 votes
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(@evogtmann)

AoU Research Priorities Use Cases

Are microbial tumor characteristics predictive of cancer treatment effects and survival?

Microbiota has been found in tumor tissues and these communities are often found to differ from the neighboring healthy tissue. Current studies tend to be small and from single cancer centers. We propose collecting tumor samples for microbial analysis in conjunction with cancer treatment data to evaluate microbial characteristics which predict successful treatment. Comparisons can be made to evaluate microbial compositions... more »

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5 votes
Ideate
(@evogtmann)

AoU Research Priorities Use Cases

Are microbial tumor characteristics predictive of cancer treatment effects and survival?

Microbiota has been found in tumor tissues and these communities are often found to differ from the neighboring healthy tissue. Current studies tend to be small and from single cancer centers. We propose collecting tumor samples for microbial analysis in conjunction with cancer treatment data to evaluate microbial characteristics which predict successful treatment. Comparisons can be made to evaluate microbial compositions... more »

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5 votes
Ideate
(@raodiv)

AoU Research Priorities Use Cases

Develop and validate simple user friendly modalities to reduce patient wait times to improve cancer survival and outcomes

Mobile health platforms may be developed and validated to reduce patient wait times between primary care physician's referral and obtaining appropriate care from a specialist. The modalities may navigate patient in the identification of a specialist, making appointment with the specialist(s), facilitate faster diagnostics and treatment decisions, increase access to needed care, improve patient adherence to treatment and... more »

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6 votes
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