(@blp2125)

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Would evalutation of environemental exposure history measured in deciduous teeth improve disease liability assessment?

Sophisticated laboratory techniques can now extract levels of exposure to numerous trace organic and inorganic contaminants and medications in the layers of tooth enamel- giving timestamped exposure (temporal) sensitivity. This represents a massive step forward because recall, or chronic measurement of place and exposure is not necessary, but is nevertheless important in defining exposure-outcome relationships. Participants... more »

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(@jatkinso)

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What genetic factors and environmental factors are associated with dental caries?

Dental caries affects 90% of US adults and is more severe in underserved populations. Caries is caused by a complex biofilm and severity is influenced by dietary intake of sugars. Recent studies have identified caries-susceptibility alleles, some of which may be modified by fluoride use. However, more studies are needed in diverse populations. Understanding genetic factors influencing dental caries may improve caries... more »

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(@jatkinso)

AoU Research Priorities Use Cases

What genetic factors are associated with aggressive periodontitis?

Aggressive periodontitis (AgP) is a severe type of periodontal disease (PD) that affects younger patients (< 30 years), with the highest prevalence in populations of African descent. Features include bone loss around teeth, familial aggregation, and altered neutrophil function. Unraveling the genetic architecture of AgP may help us understand the molecular mechanisms underlying AgP and chronic PD, and could identify... more »

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