(@bcallagh)

AoU Research Priorities Use Cases

Genetic, Environmental, and Behavioral contributions to diabetic neuropathy

Peripheral neuropathy is common in persons with diabetes and those over 40, and can be measured with validated claims data. The main disease risk factors, other than hyperglycemia, are unknown. We propose a first in kind study to simultaneously address how behavioral (diet, exercise, sleep), environmental (air quality, food access), and genetic factors influence the development of neuropathy and whether these factors... more »

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1 vote
Ideate
(@haraneta)

AoU Research Priorities Use Cases

Are there sensitive and specific biomarkers to assess isolated postchallenge hyperglycemia in Hawaiians and Asian-Americans?

Asian Americans have the highest prevalence (51%) of undiagnosed type 2 diabetes (T2D), and half of Asian-Americans and Native Hawaiians with newly diagnosed T2D have isolated post-challenge hyperglycemia (iPCH). They might remain undiagnosed or experience delayed T2D if screening practices are limited to glycosylated hemoglobin and fasting plasma glucose measures. Identification of novel biomarkers to identify individuals... more »

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6 votes
Ideate
(@chymlarisma)

AoU Research Priorities Use Cases

how can intravenous insulin therapy help diabetics in controlling their disease in an out patient scenario?

This is 26-wk study of 60 patients in 2:1 ratio, cohort 1 on standard of care (SOC) & IV Insulin Infusion vs SOC alone for diabetes. Patients labs (HA1c, C-peptide, Insulin, CrClearance), BP, HR, and evidence of Neuropathy, retinopathy, nephropathy, Fatigue and hypertension will be measured at the beginning of the study, then every 12 weeks thereafter. After the first 12 weeks, the cohort 2 will cross-over to cohort... more »

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3 votes
Ideate
(@vshah92)

AoU Research Priorities Use Cases

Changes involved in the progression of T2D and development of complications is apparent at the pre-DM state or during the transi

Changes involved in the progression of T2D and development of complications is apparent at the pre-DM state or during the transition to T2D or with complications. Conducting ‘Omics’ including DNA methylation, metabolomics and microbiome studies in blood, saliva and Fecal samples allows to validate interactions of metabolites to microbiota to epigenetic regulations.

Voting

6 votes
Ideate
(@ziggeyz13)

AoU Research Priorities Use Cases

Conduct research to determine if chronic conditions such as diabetes can be improved through non-medication methods

There is a lot of controversy on whether a disease can be treated based primarily on a change of diet. With this study I would test the theory with participants from various groups to determine if the condition could be improved through diet and also determine is medication is needed for improvement

Voting

15 votes
Ideate
(@dgold217)

AoU Research Priorities Use Cases

Does a diet high in carbohydrates contribute to obesity and diabetes?

The typical American diet, defined by high quantities of processed carbohydrates, and not high fat, has led to an obesity epidemic in the United States and well as skyrocketing diabetes. I propose to analyze the number of carbohydrate grams consumed in two test groups, the typical American diet (control) and test subjects who identify themselves as “keto” or “low carb” to confirm that a low carbohydrate diet is the key... more »

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16 votes
Ideate
(@artgoddess80)

AoU Research Priorities Use Cases

What predisposing conditions increase the risk of PCOS?

Analysis of conditions that increase the risk of PCOS, particularly genetics and environment, such as endocrine disruptors and diet/gut microbiology. PCOS can lead to many long-term health problems in women, such as type 2 diabetes, cardiovascular disease, depression, and hormone related cancers. Identifying susceptible individuals would help to individualize treatment strategies. Additionally, research into the use of... more »

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11 votes
Ideate
(@nichd.allofus)

AoU Research Priorities Use Cases

What genetic markers predict consequences of pregnancy associated hypertension & gestational diabetes for mothers & offspring?

This study will focus on women who are pregnant at enrollment or become pregnant during the study and the offspring of observed pregnancies. The information will help to define genetic and epigenetic predictors of long-term effects of common pregnancy complications.

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26 votes
Ideate
(@chrysalissc)

AoU Research Priorities Use Cases

Is a culturally adapted version of the DPP more effective than a non-standard version in preventing new diabetes diagnoses?

Goals: To address the health disparities related to Type 2 diabetes among racial/ethnic minorities, by identifying best practices for cultural adaptation of health behavior interventions, and pilot-testing evidenced-based interventions with these populations. Methods: Community-based participatory research. Testing concordance of race/ethnicity of facilitators and participants. Outcomes: Increased minority participation... more »

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6 votes
Ideate