(@hhenrylai)

AoU Research Priorities Use Cases

What are the biological, environmental, and behavioral factors associated with the longitudinal trends of interstitial cystitis?

Interstitial cystitis (IC) is defined by the hallmark symptoms of chronic pelvic or bladder pain, often accompanied by urgency or frequency of urination. Using data from over 1 million men and women, we will examine the natural history and longitudinal trends of IC symptoms over 10 years in a diverse population that are traditionally underrepresented in IC research. We will also examine the biological, environmental,... more »

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6 votes
Ideate
(@hhenrylai)

AoU Research Priorities Use Cases

What are the biological, behavioral and metabolic factors that predict response vs non-response to overactive bladder treatment?

One out of 6 adults in the US (33 millions) and one out of 10 worldwide (546 millions) are affected by overactive bladder (OAB). Despite the high economic cost ($82 billions by 2020), treatment response to OAB remains suboptimal. Using data from over 1 million men and women, we will identify biological (eg, genomics, ethnicity, medical history), behavioral (lifestyle), and metabolic factors (eg, metabolic syndrome, obesity)... more »

Voting

8 votes
Ideate
(@jenna.norton)

AoU Research Priorities Use Cases

Can inclusion of erectile dysfunction (ED) improve prediction of incident cardiovascular disease (CVD)?

Recent epidemiological evidence shows ED is associated with CVD, suggesting ED may be a prodrome of CVD. We proposed to assess associations between ED preceding CVD to confirm this association in the large and diverse All of Us cohort. Additionally, ED will be added to the existing Framingham risk prediction equation to determine if inclusion of ED improves the model.

Voting

7 votes
Ideate
(@jenna.norton)

AoU Research Priorities Use Cases

Can inclusion of erectile dysfunction (ED) improve prediction of incident cardiovascular disease (CVD)?

Recent epidemiological evidence shows ED is associated with CVD, suggesting ED may be a prodrome of CVD. We proposed to assess associations between ED preceding CVD to confirm this association in the large and diverse All of Us cohort. Additionally, ED will be added to the existing Framingham risk prediction equation to determine if inclusion of ED improves the model.

Voting

7 votes
Ideate
(@jenna.norton)

AoU Research Priorities Use Cases

What characteristics are associated with urinary stone recurrence in persons with prior episode of urinary stone disease?

Urinary stone disease is burdensome and costly, and frequently recurs. Via the EHR and qualitative/quantitative methods, we will identify person and intervention characteristics associated with urinary stone recurrence. Factors associated with recurrence may provide potential treatment targets for preventing stone recurrence.

Voting

11 votes
Ideate
(@jenna.norton)

AoU Research Priorities Use Cases

How do outcomes compare for individuals with urinary tract infection treated with and without antibiotics?

Antibiotics have long been the standard of care for treatment of urinary tract infections (UTI). However, UTI may be successfully managed without antibiotics, thereby reducing unnecessary contributions to antibiotic resistance. We proposed to compare outcomes (e.g., pyelonephritis, sepsis, GI distress/ diarrhea) in individuals with UTI treated with and without antibiotics, controlling for potential confounders (infection... more »

Voting

24 votes
Ideate
(@jenna.norton)

AoU Research Priorities Use Cases

What characteristics are associated with maintenance of increased water intake in persons with urinary stone disease?

Increased water intake reduces stone recurrence, but maintaining increased intake is challenging. Via the EHR and qualitative/quantitative methods, we will identify person and intervention characteristics associated with maintenance of increased intake to determine factors that facilitate intervention success and/or enable targeted interventions. Findings may provide insights into strategies for maintenance of behavior... more »

Voting

11 votes
Ideate
(@arianasmith)

AoU Research Priorities Use Cases

Do self-reported Nocturia episodes correlate with actual nighttime visits to the toilet; what is the natural history of nocturia

Nocturia is highly prevalent and has significant impact on quality of life. Therapeutic interventions often reduce nocturia episodes by less than one episode per night and rely on self-report data to quantify efficacy. This study will identify a cohort with nocturia and compare self-reported nocturia to actual nighttime visits to the toilet as recorded by wearable technology; and follow over time. We hypothesize that... more »

Voting

21 votes
Ideate
(@jenna.norton)

AoU Research Priorities Use Cases

Does surgery to relieve obstruction from benign prostate enlargement (BPE) improve metabolic risk profile (MRP)?

Frequent and urgent urination secondary to obstruction from prostate enlargement may reduce physical activity and adherence to diuretics, thereby increasing metabolic risk profile. This study will identify a prospective subcohort of men with incident surgery to relieve bladder outlet obstruction (BOO). We hypothesize relief of LUTS will decrease need to urinate, increase level of physical activity, and reduce MRP. Patient... more »

Voting

17 votes
Ideate
(@jenna.norton)

AoU Research Priorities Use Cases

Does midurethral sling surgery (MuSS) for stress urinary incontinence (SUI) improve metabolic risk profile?

SUI may contribute to reduced physical activity and poorer adherence to diuretics, thereby increasing metabolic risk profile. This study will identify a prospective subcohort of women aged 18+ with incident MuSS to compare metabolic risk profile before and after successful surgery. We hypothesize successful MuSS will decrease need to urinate during day, increase level of physical activity, and reduce metabolic risk. Patient... more »

Voting

17 votes
Ideate
(@jenna.norton)

AoU Research Priorities Use Cases

Does midurethral sling surgery (MuSS) for stress urinary incontinence (SUI) improve metabolic risk profile?

SUI may contribute to reduced physical activity and poorer adherence to diuretics, thereby increasing metabolic risk profile. This study will identify a prospective subcohort of women aged 18+ with incident MuSS to compare metabolic risk profile before and after successful surgery. We hypothesize successful MuSS will decrease need to urinate during day, increase level of physical activity, and reduce metabolic risk. Patient... more »

Voting

17 votes
Ideate