(@hhenrylai)

AoU Research Priorities Use Cases

What are the biological and behavioral factors that predict mesh complications after sling for stress urinary incontinence?

Stress urinary incontinence (SUI) is prevalent among women, yet the standard of care treatment – midurethral mesh sling – can lead in devastating mesh complications (dyspareunia that precludes sex, chronic pelvic pain, infection). Using national data, we will identify biological (eg, genomics, vaginal & urinary microbiome, race, comorbidities, metabolic syndrome) and behavioral (eg, smoking, physical activity) factors... more »

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2 votes
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(@hhenrylai)

AoU Research Priorities Use Cases

What are the biological, environmental, and behavioral factors associated with the longitudinal trends of interstitial cystitis?

Interstitial cystitis (IC) is defined by the hallmark symptoms of chronic pelvic or bladder pain, often accompanied by urgency or frequency of urination. Using data from over 1 million men and women, we will examine the natural history and longitudinal trends of IC symptoms over 10 years in a diverse population that are traditionally underrepresented in IC research. We will also examine the biological, environmental,... more »

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6 votes
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(@hhenrylai)

AoU Research Priorities Use Cases

What are the biological, environmental, and behavioral factors associated with the longitudinal trends of interstitial cystitis?

Interstitial cystitis (IC) is defined by the hallmark symptoms of chronic pelvic or bladder pain, often accompanied by urgency or frequency of urination. Using data from over 1 million men and women, we will examine the natural history and longitudinal trends of IC symptoms over 10 years in a diverse population that are traditionally underrepresented in IC research. We will also examine the biological, environmental,... more »

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6 votes
Ideate
(@hhenrylai)

AoU Research Priorities Use Cases

What are the biological, behavioral and metabolic factors that predict response vs non-response to overactive bladder treatment?

One out of 6 adults in the US (33 millions) and one out of 10 worldwide (546 millions) are affected by overactive bladder (OAB). Despite the high economic cost ($82 billions by 2020), treatment response to OAB remains suboptimal. Using data from over 1 million men and women, we will identify biological (eg, genomics, ethnicity, medical history), behavioral (lifestyle), and metabolic factors (eg, metabolic syndrome, obesity)... more »

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8 votes
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(@abrsmith)

AoU Research Priorities Use Cases

Different types of physical activity are associated with an increase or decrease in the risk of urinary symptoms in older adults

Lower urinary tract symptoms (LUTS, eg incontinence, overactive bladder, slow urinary stream) negatively affect quality of life of many individuals as they age, yet some people never experience LUTS. Different types of physical activity (eg walking versus heavy lifting) may protect against or increase the risk of LUTS. We propose to identify people >65 years old, with and without LUTS, and identify how physical activities... more »

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33 votes
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