(@cavin.ward)

AoU Research Priorities Use Cases

What are the molecular factors of heightened sensitivity to air pollution?

Defining heightened sensitivity as an increased hazard ratio for an association between air pollution and a health outcome, identify subsets of the population based on molecular factors, e.g. genetic variants, hypermethylated regions, which are at increases risk of adverse cardiovascular or pulmonary events during high air pollution days.

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(@drirene)

AoU Research Priorities Use Cases

Could the Precision Medicine Initiative Reduce Social Inequality?

The proposed study would identify microbial communities and metabolic profiles associated with stigmatized conditions such as idiopathic malodor or mental health. Working with systemic malodor/PATM community provides unprecedented opportunities to explore biomarkers of depression, social stress, diabetes, inflammatory diseases, dental, cardiovascular, and digestive health, exposure to antibiotics, lifestyle & dietary ...more »

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219 votes
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(@geneticfp)

AoU Research Priorities Use Cases

What is the population genetics of genes that code for drug-metabolizing enzymes? Do any correlate with drug reactions?

1) Collect the genetics of drug metabolizing enzymes from the genetic samples in the All Of Us study. 2) Describe the population genetics of these specific genes. How many people are normal (extensive metabolizers, EMs)? How many have other profiles? How many genes is the "average person" abnormal for? 3) By collecting data for "allergies" (some of which are intolerances, not true allergies) and medication reactions requiring ...more »

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14 votes
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