Showing 34 ideas for tag "cancer"
(@jatkinso) kudos icon +

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What genetic factors are associated with oral cancer (OC) and oropharyngeal cancer (OPC)?

Tobacco and alcohol use and persistent oral infection with human papillomavirus (HPV) are risk factors for oral cancer (OC) and oropharyngeal cancer (OPC). CDC estimates that approximately 60% of OPC cases in the United States are caused by HPV types 16/18. Previous studies (GWAS) suggest genetic factors are associated with an increased risk of developing HPV-related OPCs. Assessing genetic factors in a large population... more »

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42 votes
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(@renaissance) kudos icon +

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How reliably do epigenetic aging clocks predict disease onset and mortality? Can they be slowed or reversed?

An annual blood test with analysis of methylation sites from key epigenetic aging clocks (e.g. Horvath). Epigenetic aging clocks have already been shown to reliably predict age, time-to-death, all cause mortality, cog. function, immune function, CV disease, cancer, and more. They may also become a key tool to demonstrate the reversibility of disease risk through dietary and therapeutic regimens, as epigenetic states are... more »

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35 votes
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(@sjogrens.syndrome.foundation) kudos icon +

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What are the pathogenic mechanisms leading to the development of blood cancers in autoimmune disease patients?

Patients with autoimmune diseases have been found to be at a higher risk of certain types of cancers, particularly hematologic cancers. A recent study found that patients with Sjögren's were eleven times more likely to develop a hematologic cancer compared to patients without Sjögren's. The purpose of this study is to identify the pathogenic mechanisms leading to the development of blood and other cancers in patients... more »

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22 votes
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(@riscutag2) kudos icon +

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Evaluate Age-related Microbiota Changes and their impact in Health, and in Chronic Disease Prevention, Treatment and Progression

The microbiome variations have been associated with health and disease status in cross-sectional studies. There is a need to examine these associations in a longitudinal fashion and to establish baseline changes in health and disease over a lifespan. All of Us Together provides a game-changing amount of longitudinal data on enough individuals to begin to map the complex relationship between exposures (diet, antibiotics,... more »

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19 votes
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(@changhu) kudos icon +

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What are the long-term cardiovascular effects of cancer therapy? Do childhood cancer survivors have reduced cardiac functions?

To study adult cancer survivors who received cancer therapy during childhood. What are their cardiovascular functions as compared to adults who did not receive cancer therapy. Reduction of cardiovascular functions after anticancer therapy may take years to develop. These undesirable complications can compromise quality of life or shorten life span. This study will provide evidence-based guidelines for physicians to choose... more »

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17 votes
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(@deesparacio) kudos icon +

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Use genetic sequencing to Identify what factors account for some individuals to live to 100 years without developing canc

Identify the population of individuals who are age 100 years half who may have had a cancer diagnosis and half with no cancer diagnosis in their lifetime.
Survey those individuals as to their life experiences - medical history, employment history, lifestyle, exercise history, diet etc
Individuals will provide a blood sample for complete genetic analysis.
What genetic mutations are present which may cause cancer yet... more »

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13 votes
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(@changhu) kudos icon +

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What are the genetic, comorbid risk factors, and anticancer agents that contribute to heart failure after cancer therapy

Goals:To study the epidemiology of cardiovascular complications of cancer therapy in order to design prevention strategy and precision treatment of cancer patients while minimizing debilitating cardiovascular complications. Methods: compare data on genetic, co morbid risk factors, and anticancer agents used in association with cardiovascular complications after cancer therapy. Expected outcomes: This study will provide... more »

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11 votes
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(@svogelstein) kudos icon +

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What is the long-term impact of consumption of organic foods on health outcomes?

Organic foods are thought to be healthier than conventional foods because of the limited exposure to pesticides and other chemicals. Few studies have examined the long-term health effects of organic foods. By collecting information on organic food consumption and comparing those who tend to consume more organic foods (e.g., organic fruits/veg) to those who consume less, we could evaluate the impact of organic food consumption... more »

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11 votes
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(@raodiv) kudos icon +

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Role of Persistent Co-infections in Health and Disease

Co-infections can significantly alter disease risk, incidence, prevalence, aggressiveness, treatment response and outcomes, in addition to, making it more difficult to manage and treat the diseases. Compare differences in host response to co-infections, disease risk and treatment response to elucidate how the ubiquitous co-infections contribute to variations in disease incidence and outcomes.

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9 votes
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(@raodiv) kudos icon +

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Develop and validate simple user friendly modalities to reduce patient wait times to improve cancer survival and outcomes

Mobile health platforms may be developed and validated to reduce patient wait times between primary care physician's referral and obtaining appropriate care from a specialist. The modalities may navigate patient in the identification of a specialist, making appointment with the specialist(s), facilitate faster diagnostics and treatment decisions, increase access to needed care, improve patient adherence to treatment and... more »

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6 votes
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(@gadallas) kudos icon +

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Can we build precise cancer risk prediction models that may guide early diagnosis

The early detection of cancer improved treatment outcomes and patient survival. Building precise risk prediction models can personalize cancer screening programs to ones need. The integration of variables capturing changes in lifestyle factors, exposure history, and molecular markers overtime, together with the opportunity for passive surveillance through data linkage to electronic medical records and cancer registries... more »

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6 votes
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(@maria.spletter) kudos icon +

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Does data from deep sequencing tumors (personalized medicine) allow for targeted treatment and better survival of patients?

1. Divide "cancer" into multiple classes (ie breast, lung, pancreatic, etc.) and sequence tumors from 50-100 patients undergoing treatment. As with breast cancer, identify markers aligning with specific treatments and outcomes.
2. Perform the "clinical" trial. Use the deep sequencing as a diagnostic to aid in planning the treatment for a set of 50-100 patients for a given type of cancer. Track the outcomes: survival time,... more »

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5 votes
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(@lisa.signorello) kudos icon +

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To what extent are adverse childhood experiences (ACE) or trauma related to a wide range of adult diseases or premature death?

Adverse childhood experiences (ACE) can be retrospectively assessed in adults, ideally before the onset of the diseases under study. There are existing ACE instruments, or attempts to refine these instruments could be undertaken within All of Us.

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5 votes
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(@svogelstein) kudos icon +

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Are pesticides associated with cancer risk?

Pesticides are commonly used inside and outside the home. Evidence from studies of farmers suggests that some pesticides are likely carcinogenic, but the impact of lower levels of exposure is less clear. By collecting information on pesticide exposure through surveys and analysis of carpet dust, we could evaluate the risk of cancer associated with low levels of pesticide exposure. Given their widespread use, even a small... more »

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4 votes
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