(@drirene)

AoU Research Priorities Use Cases

Could the Precision Medicine Initiative Reduce Social Inequality?

The proposed study would identify microbial communities and metabolic profiles associated with stigmatized conditions such as idiopathic malodor or mental health. Working with systemic malodor/PATM community provides unprecedented opportunities to explore biomarkers of depression, social stress, diabetes, inflammatory diseases, dental, cardiovascular, and digestive health, exposure to antibiotics, lifestyle & dietary... more »

Voting

219 votes
Ideate
(@nichd.allofus)

AoU Research Priorities Use Cases

What microbiome characteristics of children exposed to antibiotics and different diets influence long-term health outcomes?

Follow a subsample of all infants and children (< 3 years of age) throughout childhood to obtain the following serial assessments: blood tests, medication history, neonatal, infant and childhood health outcomes; physical measurements and laboratory microbiologic evaluations of oral, skin and vaginal specimens. Assessments and measures would be used along with health outcomes to determine associations and develop predictive... more »

Voting

153 votes
Ideate
(@nichd.allofus)

AoU Research Priorities Use Cases

What microbiome characteristics of children exposed to antibiotics and different diets influence long-term health outcomes?

Follow a subsample of all infants and children (< 3 years of age) throughout childhood to obtain the following serial assessments: blood tests, medication history, neonatal, infant and childhood health outcomes; physical measurements and laboratory microbiologic evaluations of oral, skin and vaginal specimens. Assessments and measures would be used along with health outcomes to determine associations and develop predictive... more »

Voting

153 votes
Ideate
(@mpwhitmire)

AoU Research Priorities Use Cases

What social determinants & health/functional factors increase the risk of malnutrition for older adults living in the community?

It is important that the All of Us database includes a range of nutrition-related measures which are used to help identify malnutrition risk. Additional measures of malnutrition-related characteristics are important for malnutrition diagnosis. Validated screening tools such as the Malnutrition Screening Tool (MST) could be used regularly to collect this data, as well as linked surveys to capture demographic information... more »

Voting

75 votes
Ideate
(@measurenutrition)

AoU Research Priorities Use Cases

What is the contribution of dietary patterns and nutritional status to chronic disease susceptibility and prevention?

The top four causes of deaths in the U.S. are diet related and many other troublesome diseases are affected by diet, It will be important therefore to capture nutritional status, food environment, and repeated 24h (ASA24s) dietary intakes along with measures that can validate dietary measures of public policy interest including added sugar, energy, protein, sodium, iron, vitamins, dietary supplements, potassium, fruits... more »

Voting

67 votes
Ideate
(@measurenutrition)

AoU Research Priorities Use Cases

What is the contribution of dietary patterns and nutritional status to chronic disease susceptibility and prevention?

The top four causes of deaths in the U.S. are diet related and many other troublesome diseases are affected by diet, It will be important therefore to capture nutritional status, food environment, and repeated 24h (ASA24s) dietary intakes along with measures that can validate dietary measures of public policy interest including added sugar, energy, protein, sodium, iron, vitamins, dietary supplements, potassium, fruits... more »

Voting

67 votes
Ideate
(@zenknutrition)

AoU Research Priorities Use Cases

How do local, regional, state, and national retail food environments and policies affect diet and health?

Obesity and poor diet are threats to population health. The food environment and related policies may be major contributors. Longitudinal measures of food purchasing, diet, and health can be linked to environmental/policy data (eg community gardens, changes in convenience store offerings, fast food moratoriums, menu labeling, food taxes/subsidies), and used to identify health effects. Results can help prioritize multilevel... more »

Voting

55 votes
Ideate
(@barbaral)

AoU Research Priorities Use Cases

The low-fat diet has resulted in a high-sugar diet in the US. Conflicting info results. How should we be eating?

Would like to look at dietary features and compare with incidence of hypertension, diabetes, cancer and alzheimers.

What oil (s) people use?

Whether they avoid gluten?

Whether they eat moderate red meat?

Whether they eat low-fat or fat-free foods?

Whether they eat cold breakfast cereal?

How often they eat nitrate containing meats (bacon, salami, etc.)?

Are there any proven dietary correlations with Alzheimer's?

Voting

48 votes
Ideate
(@nichd.allofus)

AoU Research Priorities Use Cases

What characteristics distinguish a healthy maternal pregnancy-microbiome from one that experienced microbial perturbations?

This study will focus on a subsample of all pregnant women and follow them throughout pregnancy to obtain serial assessments and measurements, including laboratory microbiologic evaluation testing of oral, skin and vaginal specimens. Follow-up would end at delivery of the infant; serial pregnancies would be eligible to re-enroll. Assessments and measures would be used along with health outcomes to determine associations... more »

Voting

43 votes
Ideate
(@nichd.allofus)

AoU Research Priorities Use Cases

What characteristics distinguish a healthy maternal pregnancy-microbiome from one that experienced microbial perturbations?

This study will focus on a subsample of all pregnant women and follow them throughout pregnancy to obtain serial assessments and measurements, including laboratory microbiologic evaluation testing of oral, skin and vaginal specimens. Follow-up would end at delivery of the infant; serial pregnancies would be eligible to re-enroll. Assessments and measures would be used along with health outcomes to determine associations... more »

Voting

43 votes
Ideate
(@karen.montefiori)

AoU Research Priorities Use Cases

How does a life-long adherence to healthy life style habits affect the aging process?

Goal: Show that a strict, and life-long adherence to a healthy life style retards the aging process, enables you to avoid many common diseases, and allows you to greatly reduce healthcare costs. Method: Invite participants from all over the world to commit to following a healthy life style regimen throughout life. Expected outcomes: Participates age more slowly, have fewer chronic diseases, and spend less on health... more »

Voting

33 votes
Ideate
(@cpeterso)

AoU Research Priorities Use Cases

How do different food groups affect health?

Administer food diaries and assess the impact of food groups/categories, such as fruits, root vegetables, green leafy vegetables, all other vegetables, low-fat dairy, full fat dairy, fish, white meat, red meat, processed meat, nuts & seeds, beans/legumes, whole grains made from flour (pasta, bread, pastries), intact whole grains (i.e., whole grain products not made from flour), refined grains, refined sugar, oils, etc.... more »

Voting

24 votes
Ideate
(@bcarverme)

AoU Research Priorities Use Cases

Investigate the role of environmental and dietary factors in the incidence of chronic pain

Investigate the correlation between the incidence of reported pain and various social and biological characteristics. Investigate the correlation between the incidence of reported pain and dietary factors including foods, food additives such as dyes, preservatives and other additives. Investigate the correlation between the incidence of reported pain and environmental exposures including pollution, pesticides and the... more »

Voting

23 votes
Ideate
(@subara)

AoU Research Priorities Use Cases

What are the associations between diet and health outcomes?

Dietary intake is a complex and dynamic exposure known to affect health. To best assess foods, nutrients, dietary supplements and dietary patterns and any latency in their relationship to disease, longitudinal collection every year of both long- and short-term dietary assessment instruments is necessary. To fully adjust for systematic error, replicated recovery and predictive biomarkers should be collected in a 10-20%... more »

Voting

18 votes
Ideate