Showing 22 ideas for tag "microbiome"
(@drirene) kudos icon +

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Could the Precision Medicine Initiative Reduce Social Inequality?

The proposed study would identify microbial communities and metabolic profiles associated with stigmatized conditions such as idiopathic malodor or mental health.
Working with systemic malodor/PATM community provides unprecedented opportunities to explore biomarkers of depression, social stress, diabetes, inflammatory diseases, dental, cardiovascular, and digestive health, exposure to antibiotics, lifestyle & dietary... more »

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219 votes
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(@nichd.allofus) kudos icon +

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What are the unique factors associated with early onset obesity in different ethnic and racial groups?

This study will focus on women who are pregnant when they enroll, or become pregnant during the study, in order to follow their infants from birth to 8 years of age to determine trajectories of growth over time and identify genomic and epigenomic factors related to development of obesity. Critical to obtaining this information will be the review of Electronic Health Records of providers who have the correct measuring... more »

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155 votes
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(@nichd.allofus) kudos icon +

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What microbiome characteristics of children exposed to antibiotics and different diets influence long-term health outcomes?

Follow a subsample of all infants and children (< 3 years of age) throughout childhood to obtain the following serial assessments: blood tests, medication history, neonatal, infant and childhood health outcomes; physical measurements and laboratory microbiologic evaluations of oral, skin and vaginal specimens. Assessments and measures would be used along with health outcomes to determine associations and develop predictive... more »

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153 votes
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(@ermueller) kudos icon +

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What is the impact of fluid intake on health?

There is a fluid intake range that is healthy. Below this level predisposes to urinary tract infections, urinary stone formation, changes in the gut and urinary micro biome, and results in generalized symptoms of well-being. Fluid intake above a healthy threshold predisposes to lower urinary tract symptoms, sleep interruptions and may affect symptoms of well-being.

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48 votes
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(@nichd.allofus) kudos icon +

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What characteristics distinguish a healthy maternal pregnancy-microbiome from one that experienced microbial perturbations?

This study will focus on a subsample of all pregnant women and follow them throughout pregnancy to obtain serial assessments and measurements, including laboratory microbiologic evaluation testing of oral, skin and vaginal specimens. Follow-up would end at delivery of the infant; serial pregnancies would be eligible to re-enroll. Assessments and measures would be used along with health outcomes to determine associations... more »

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43 votes
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(@sjogrens.syndrome.foundation) kudos icon +

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How can we translate knowledge about the microbiome into better ways to diagnose and treat autoimmune diseases?

The scientific and medical communities are rapidly learning more about the human microbiome and the role it plays in our health, but there are still many gaps that need to be addressed. The purpose of this study would be to focus on identifying the relationship between the microbiome and a systemic disease state, helping to inform new methods for translating knowledge about the micriobiome into better, more efficient... more »

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40 votes
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(@idsociety) kudos icon +

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Using human microbiome data to improve pathogenesis and treatment of infectious diseases

Precision microbiome engineering could be applied to vaccine delivery, immunology, drug-resistant infections, and post-surgical infections.

Specific research questions re pathogenesis and treatment:

- What aspects of the indigenous microbiota mediate colonization resistance against C. difficile, as well as other multi-drug resistant organisms such as carbapenamase-producing gram negative bacteria and vancomycin resistant... more »

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31 votes
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(@evogtmann) kudos icon +

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Is the human oral and fecal microbiota associated with chronic disease risk factors, such as obesity and metabolic syndrome?

The human microbiota has been found to be associated with a number of health conditions, such as obesity. However, these studies have been relatively small and from convenience samples. It is important to understand how the human microbiota impacts these chronic disease risk factors in order to prevent future disease development. We propose collecting oral and fecal samples to determine associations with many chronic... more »

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28 votes
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(@idsociety) kudos icon +

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How can AoU data be harnessed to improve infectious diseases patient care, diagnostics, vaccinolology, and drug development?

How is precision medicine as it applies to infectious diseases different than how it is considered for Oncology or other fields?

• Time-pressured setting (e.g., initiating therapy for a hospital acquired or ventilator-associated bacterial pneumonia patient)

• Microbiome vs. human genome

• Intersections with other cognitive and procedural specialties across the board

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21 votes
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(@riscutag2) kudos icon +

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Evaluate Age-related Microbiota Changes and their impact in Health, and in Chronic Disease Prevention, Treatment and Progression

The microbiome variations have been associated with health and disease status in cross-sectional studies. There is a need to examine these associations in a longitudinal fashion and to establish baseline changes in health and disease over a lifespan. All of Us Together provides a game-changing amount of longitudinal data on enough individuals to begin to map the complex relationship between exposures (diet, antibiotics,... more »

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19 votes
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(@rborban) kudos icon +

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Can we develop a protocol to assess for Leaky Gut self help regimen to follow to heal the gut and establish a healtjy gut

1. Questionaire to assess for Leaky Gut.

2. Lab tests to assess for abnormal Intestinal flora.

3. Serum lab tests to assess for inflamation in body.

4. Dietary and nutritional supplement protocol to follow to establish healthy gut microbiome.

5. Correlate positive leaky gut diagnosis with other medical disorders present in the subject.

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15 votes
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(@blp2125) kudos icon +

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Could adding fecal sampling to the "All of Us" campaign help resolve role of gut microbiome in complex disease risk?

The simple addition of fecal sample for the use of gut microbiome taxonomical assessment could prove a valuable resource for testing hypotheses about the gut flora as a target of, and contributor to myriad human health and disease states. Fecal sample collection is non-invasive and gut bacterial lab methods are becoming increasingly refined and high-throughput.

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15 votes
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(@floresr2) kudos icon +

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Dietary and microbial-derived metabolites may modulate body weight and contribute to overweight and obesity.

Integrate multi-omic approaches (metabolomic, proteomic, inflammasome, microbiome analyses) with dietary assessment and clinical data in a nested cohort study. Dietary and/or microbial metabolites may modulate body weight and may influence other comorbidities. A comprehensive analysis of inflammatory and metabolic biomarkers of oxidative stress, nutritional assessment, short chain fatty acids and other microbial metabolites... more »

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14 votes
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(@vshah92) kudos icon +

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Changes involved in the progression of T2D and development of complications is apparent at the pre-DM state or during the transi

Changes involved in the progression of T2D and development of complications is apparent at the pre-DM state or during the transition to T2D or with complications. Conducting ‘Omics’ including DNA methylation, metabolomics and microbiome studies in blood, saliva and Fecal samples allows to validate interactions of metabolites to microbiota to epigenetic regulations.

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6 votes
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Genetic, epigenetic, and microbiome contributions to hypertension

The goal would be to enhance our understanding of how social and environmental exposures, genomic factors, and gut microbiota interact to influence hypertension susceptibility and phenotype. This would require integrated analyses of genomic and other -omics data, exposures, and phenotype data, and could lead to insights that enable more targeted prevention and treatment. Inherent in this would be discovery of pathways... more »

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6 votes
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