(@jatkinso)

AoU Research Priorities Use Cases

What genes are associated with temporomandibular joint dysfunction (TMD) and its co-morbid pain conditions?

Temporomandibular joint disorder (TMD), is a group of conditions that cause pain and dysfunction in the jaw joint and muscles that control jaw movement. The 2014 US National Health Interview Survey reported 4.6% of adults reported pain in the face or jaw in the previous 3 months. TMD often overlaps with other pain disorders, including headache, low back pain, and chronic widespread pain. Identification of genes and gene... more »

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41 votes
Ideate
(@nfschor)

AoU Research Priorities Use Cases

Are there patient characteristics that predict resilience to and coping strategies and treatments chosen for recurrent pain?

Identify subsets of All of Us participants with chronic pain of various types. Administer questionnaire that asks in general about coping mechanisms, self-perceived pain tolerance, interference of pain disorder with function, child and adult exposures to adverse life experiences, history of depression/PTSD, drivers of decision of whether or not to treat an episode of pain, use of pharmacological therapies, use of non-pharmacological... more »

Voting

59 votes
Ideate
(@sjogrens.syndrome.foundation)

AoU Research Priorities Use Cases

Can we find better treatments for neuropathic numbness and pain in Sjögren's and other autoimmune diseases?

Peripheral neuropathies are common in Sjögren's and related autoimmune diseases and can be a presenting symptom of Sjögren's. Burning pain and numbness in the extremities, trigeminal neuralgias, weakness, poor balance and altered gait can occur. Symptoms can interfere greatly with quality of life and function. This study would focus on identifying better treatments to address these symptoms in Sjögren's and autoimmune... more »

Voting

26 votes
Ideate
(@sjogrens.syndrome.foundation)

AoU Research Priorities Use Cases

Can we find better treatments for neuropathic numbness and pain in Sjögren's and other autoimmune diseases?

Peripheral neuropathies are common in Sjögren's and related autoimmune diseases and can be a presenting symptom of Sjögren's. Burning pain and numbness in the extremities, trigeminal neuralgias, weakness, poor balance and altered gait can occur. Symptoms can interfere greatly with quality of life and function. This study would focus on identifying better treatments to address these symptoms in Sjögren's and autoimmune... more »

Voting

26 votes
Ideate
(@bcarverme)

AoU Research Priorities Use Cases

Investigate the role of environmental and dietary factors in the incidence of chronic pain

Investigate the correlation between the incidence of reported pain and various social and biological characteristics. Investigate the correlation between the incidence of reported pain and dietary factors including foods, food additives such as dyes, preservatives and other additives. Investigate the correlation between the incidence of reported pain and environmental exposures including pollution, pesticides and the... more »

Voting

23 votes
Ideate
(@ben.dorshorst)

AoU Research Priorities Use Cases

Is there a genetic component to conditions such as fibromyalgia, chronic pain, chronic fatigue, anxiety and depression?

Utilize existing health records, genomic and epigenomic data to identify factors that predispose or are otherwise associated with the conditions of fibromyalgia, chronic pain, chronic fatigue, anxiety and depression.

Voting

22 votes
Ideate
(@r.umrani)

AoU Research Priorities Use Cases

What is the effect of exercise on pain levels in individuals with sickle cell disease?

Goal: determine the effect of regular and structured exercise on pain levels in individuals with sickle cell disease. Method: RCT with a group who perform at least 150 mins a week of moderate physical activity eg 30 mins of weight lifting 5days/week Track daily pain levels using numeric pain rating scale from individuals in the exercise group, and the control. Can also track pain episodes and crises per individual, and... more »

Voting

11 votes
Ideate
(@yentram.huyen)

AoU Research Priorities Use Cases

EXAMPLE : What are the characteristics of people who sustain fractures, compared to those who don’t?

This study will focus on the entire cohort ages 50 or older and provide outcomes on bisphosphonate use and movement. The information will help to develop more precise strategies to target individuals who would benefit from bisphosphonates or other interventions for the prevention of bone fractures.

Voting

6 votes
Ideate
(@westrw)

AoU Research Priorities Use Cases

Which PAIN GENES/PATHWAYS are commonly expressed in patients with ARACHNOIDITIS or low back pain with radiculopathy

1. Identify patients with a diagnosis of arachnoiditis or low back pain with radiculopathy

2. Examine genetic variants, and gene expression and epigenetic status of respective genes

3. Determine if a genetic relationship among respective patient community

Voting

7 votes
Ideate
(@rwells)

AoU Research Priorities Use Cases

Can meditation be used to decrease pain medication required after a painful procedure.

If meditation training is provided before a planned painful procedure, and practiced, can it decrease the amount of analgesia needed to achieve comfort after the procedure has been performed? Patients should be offered meditation training anticipating a planned procedure and have them practice the technique for at least a week prior to the procedure. (Ideally they would not be in pain while being taught or practicing.)... more »

Voting

9 votes
Ideate
(@blacktherapistsrock)

AoU Research Priorities Use Cases

Can improvement in emotional health using psychotherapy increase physical health while reducing risk factors of obesity.

Black Therapists Rock engages over 19,000 psychotherapists who work with vulnerable populations. We have noticed a correlation of improved health outcomes in clients who have utilized Internal Family Systems (IFS), a psychotherapy model that focuses on healing the emotional wounds developed in childhood. We wish to expand upon this data, by employing more therapists to use this model, while advocating/recruiting participants... more »

Voting

8 votes
Ideate
(@hhenrylai)

AoU Research Priorities Use Cases

What are the biological, environmental, and behavioral factors associated with the longitudinal trends of interstitial cystitis?

Interstitial cystitis (IC) is defined by the hallmark symptoms of chronic pelvic or bladder pain, often accompanied by urgency or frequency of urination. Using data from over 1 million men and women, we will examine the natural history and longitudinal trends of IC symptoms over 10 years in a diverse population that are traditionally underrepresented in IC research. We will also examine the biological, environmental,... more »

Voting

6 votes
Ideate
(@hhenrylai)

AoU Research Priorities Use Cases

What are the biological, environmental, and behavioral factors associated with the longitudinal trends of interstitial cystitis?

Interstitial cystitis (IC) is defined by the hallmark symptoms of chronic pelvic or bladder pain, often accompanied by urgency or frequency of urination. Using data from over 1 million men and women, we will examine the natural history and longitudinal trends of IC symptoms over 10 years in a diverse population that are traditionally underrepresented in IC research. We will also examine the biological, environmental,... more »

Voting

6 votes
Ideate
(@dlwn83)

AoU Research Priorities Use Cases

Opioid epidemic study: can combining ultra-low-dose naltrexone with an opioid help prevent negative psychosocial outcomes?

A randomized controlled study to determine if the combination of ultra-low-dose naltrexone with an opioid can provide better psychosocial outcomes for chronic pain patients. It would compare the results of treatment with various common opioids both alone and in combination with ultra-low-dose naltrexone. The goal is to see which treatment yields the best psychosocial outcomes and pain relief. Preliminary studies suggest... more »

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4 votes
Ideate