AoU Research Priorities Use Cases

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Below are the research questions others have already entered. IdeaScale is temporarily closed, but you can read what has been submitted so far. When re-opened, you can leave a comment or vote for the ideas you like. At that time, you'll also be able to submit your own idea.

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(@nichd.allofus)

AoU Research Priorities Use Cases

How do genetic factors of ADHD influence treatment strategies? Can they affect success of treatment or the choice of therapy?

Screen school-age children for ADHD by testing, if feasible, or by electronic health record search. Perform WGS on children as the preferred strategy to identify new genetic associations and confirm previously reported genetic associations. If WGS is not possible, develop a marker panel and test children who have ADHD for known or suspected genetic factors. Follow children by periodic medical evaluations and school performance... more »

Voting

94 votes
Ideate
(@nichd.allofus)

AoU Research Priorities Use Cases

How are sleep characteristics associated with pediatric developmental conditions, disorders or chronic disease?

This study will focus on the entire cohort (infant-19 y/o) to provide health and behavior outcomes associated with sleep characteristics, including environmental and demographic factors. This information will help better define the development of sleep, help develop more precise strategies to target children with sleep characteristics predictive of poor health outcomes, and develop more precise strategies for children... more »

Voting

94 votes
Ideate
(@scherrjf)

AoU Research Priorities Use Cases

What treatments are effective in reducing anxiety and increasing stress tolerance in high-functioning, children with autism

A cohort study of pre-teens with high functioning autism, formerly Aspergers, would collect data about pharmacological and behavioral therapies tried and obtain dose and duration of treatments. Survey data from parents would measure functioning and stress tolerance at age 10, 13 and 18.

Voting

85 votes
Ideate
(@pfuller)

AoU Research Priorities Use Cases

Wearables for capturing sleep and circadian information across day/night and long-term.

Wearables that can capture sleep and circadian information-across the day/night and over time--should be included. Activity monitors, EEG, ECG and Oximetry measurement are increasingly accessible with miniaturization of technology. Consumer interest in many of these devices has accelerated development and driven costs down. Analysis of these data-perhaps using open-platforms- hold promise for deriving quantitative measurements... more »

Voting

84 votes
Ideate
(@blstone)

AoU Research Priorities Use Cases

Associations between genetics, environment, household, parenting time, and nutrition on early child development (ages 0-6)

Intensive data collection and analysis including genetic and epigenetic data over time, family history, physical environment (pollution, housing age, etc), social environment (income, household, employment/history, neighborhood, education resources, etc), nutrition, parenting (preparedness, skills, family composition, generational support, etc), early childhood stress, other exposures, demographics; to determine impact... more »

Voting

82 votes
Ideate

AoU Research Priorities Use Cases

What is the overall role of sports, which promote physical activity but can also contribute to injuries, in America’s health?

Sports play a unique role as a platform for physical activity, but can also increase the risk of injury. All of Us offers an opportunity to identify health benefits and risks of sports by population segment, sport, and level of play. A resulting "sports prescription for health" could be a powerful leap forward in improving health. Methods could include data on sports injuries, wearable technology, validated self-reports,... more »

Voting

81 votes
Ideate
(@susanpl13)

AoU Research Priorities Use Cases

Does insufficient, disordered, or mistimed sleep cause physical/mental illness?

The CDC calls insufficient sleep a "public health problem." But sleep & circadian rhythms are oft-ignored—even derided--aspects of health. When you ask subjects about lifestyle, don't stop @ diet/exercise. Ask about sleep. When you ask about sleep, don't stop @ length/quality. Ask about circadian timing: when ppl sleep. Is timing dictated by their body clock *or* work/family demands? AOU is an unprecedented opp to... more »

Voting

80 votes
Ideate
(@lathom)

AoU Research Priorities Use Cases

What are the effects of Adverse Childhood Experiences (ACEs) over the lifespan?

Much of what we know about ACEs is retrospective yet we believe that there are developmental touch points and/or aspects of resilience that help or hinder the biologic stress that may or may not ensue after an adverse experience. Monitoring parent and child adversity and stress over time will clarify a much needed field where we know that ACEs cause acceleration of physical, mental and behavioral health problems in... more »

Voting

78 votes
Ideate
(@pfuller)

AoU Research Priorities Use Cases

Characterize the bases for the circadian timing, duration and and quality of sleep and vulnerability to develop sleep disorders

Study would seek to characterize the etiological bases, including genetic, socio-cultural and environmental, for the circadian timing, duration and quality of sleep and vulnerability to develop sleep disorders.

Voting

76 votes
Ideate
(@mpwhitmire)

AoU Research Priorities Use Cases

What social determinants & health/functional factors increase the risk of malnutrition for older adults living in the community?

It is important that the All of Us database includes a range of nutrition-related measures which are used to help identify malnutrition risk. Additional measures of malnutrition-related characteristics are important for malnutrition diagnosis. Validated screening tools such as the Malnutrition Screening Tool (MST) could be used regularly to collect this data, as well as linked surveys to capture demographic information... more »

Voting

75 votes
Ideate
(@holly.nicastro)

AoU Research Priorities Use Cases

What factors predict successful long-term weight loss maintenance?

>60% of U.S. adults are classified as overweight/obese. Treatments to promote long-term weight loss (e.g. behavioral, pharmacological, surgical) are often not successful and result in high variability across individuals. Measurement of potential predictors from multiple domains (behavioral, biological, environmental, and psychosocial) can help identify the factors that best predict success in response to intentional weight... more »

Voting

73 votes
Ideate
(@jennifer.stevenslapsley)

AoU Research Priorities Use Cases

Is gait speed associated with health outcomes in a large, generalizable data set?

Numerous controlled studies suggest gait speed is a marker of overall physical function, and is predictive of a range of adverse events - including death. The All of Us data set provides a unique opportunity to explore relationships between gait speed, lifestyle factors, and health outcomes over time in a diverse, representative group of individuals. Insights gained could allow for more timely intervention by both patients... more »

Voting

72 votes
Ideate