As many as 16% of women in the U.S. suffer from vulvodynia at some point in their lives. It affects women of all ages, races, and ethnic backgrounds. Yet, the exact cause of vulvodynia is unknown due to a lack of research. As a result, treatments used to treat this condition are the same ones used for other chronic pain conditions and there is little or no proof of their efficacy. Research on the cause of this condition ...more »

The proposed study would identify microbial communities and metabolic profiles associated with stigmatized conditions such as idiopathic malodor or mental health. Working with systemic malodor/PATM community provides unprecedented opportunities to explore biomarkers of depression, social stress, diabetes, inflammatory diseases, dental, cardiovascular, and digestive health, exposure to antibiotics, lifestyle & dietary ...more »

8% of women may experience stigmatizing and debilitating chronic vulvar pain (vulvodynia) by age 40. Recurrent urogenital infections are associated with vulvodynia and women with vulvodynia may be at risk of LUTS. Vulvodynia patients fail to seek care and therefore we propose to ask women to report any period of pain during intercourse, tampon use, or at the time of a pelvic examination that lasted for at least 3 months ...more »

This study will focus on women who are pregnant when they enroll, or become pregnant during the study, in order to follow their infants from birth to 8 years of age to determine trajectories of growth over time and identify genomic and epigenomic factors related to development of obesity. Critical to obtaining this information will be the review of Electronic Health Records of providers who have the correct measuring ...more »

Follow a subsample of all infants and children (< 3 years of age) throughout childhood to obtain the following serial assessments: blood tests, medication history, neonatal, infant and childhood health outcomes; physical measurements and laboratory microbiologic evaluations of oral, skin and vaginal specimens. Assessments and measures would be used along with health outcomes to determine associations and develop predictive ...more »

Endometriosis is a systemic condition with a heavy burden on patients. It is estimated that 10% of women in reproductive age have endometriosis, but its etiology is still unknown. While it is accepted that endometriosis is a heterogeneous condition, what the exact subtypes of the disease are is still an open question.

Determine the lifestyle strategies and interventions that produce the most gains in prevention and treatment of diseases in a comparative and complementary context with pharmaceutical, surgical, and other approaches. Methods could include data collection through wearable technology, validated self-reports, comparative effectiveness data, medical reimbursement, predictive analytics, and the unique insights from All of ...more »

Goal: Prove that medically tailored home-delivered meals reduce hospital utilization for seriously ill individuals Methods: Randomized control study where the experimental group (seriously ill individuals with ADL limitations recently released from the hospital) receive 21 medically tailored meals per week (including MNT from a RDN for 9 months, while the control group receives SOC the standard of care). Patients will ...more »

Intentionally aim to ensure that All of Us insights extend to everyone, particularly regarding lifestyles and improved health for population segments of need and opportunity. Methods could include data collection through wearable technology, validated self-reports, comparative effectiveness data, medical reimbursement, predictive analytics, and the unique insights from All of Us. ACSM applauds this pathway to health innovation. ...more »

This study will focus on the entire cohort. The goal will be to determine the interaction of genomic, sociodemographic, physiologic and environmental factors for the mother and child impacted by Neonatal Opioid Withdrawal Syndrome (NOWS) and their impact on treatment response, treatment outcome, health outcomes for the mother, and developmental outcomes for the child.

A transformative goal would be to use precision medicine to individualize and make far more effective dose-response interventions and prescriptions for physical activity and other health behaviors. Methods could include data collection through wearable technology, validated self-reports, other existing health data, and the unique insights from All of Us, especially related to sources and effects of lifestyle influence. ...more »

An improved understanding of the wide-ranging interplay of community design, programs, policies, worksite health, physician counseling, and other factors in influencing health behaviors and lifestyle choices is crucial to improving health outcomes. Methods could include data collection through wearable technology, validated self-reports, medical reimbursement, predictive analytics, and the unique insights from All of ...more »