AoU Research Priorities Use Cases

See others’ ideas.

Below are the research questions others have already entered. IdeaScale is temporarily closed, but you can read what has been submitted so far. When re-opened, you can leave a comment or vote for the ideas you like. At that time, you'll also be able to submit your own idea.

When you are ready to submit your own idea after IdeaScale is re-opened, click the "Submit New Idea" button in the top right corner. Moderators from our team will review your submission and then add it to the rest of the submitted research questions.

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AoU Research Priorities Use Cases

Submitted by (@lisagoldstein)

What are the pathophysiologic factors associated with the development of vulvodynia, chronic vulvar pain without a clear cause?

As many as 16% of women in the U.S. suffer from vulvodynia at some point in their lives. It affects women of all ages, races, and ethnic backgrounds. Yet, the exact cause of vulvodynia is unknown due to a lack of research. As a result, treatments used to treat this condition are the same ones used for other chronic pain conditions and there is little or no proof of their efficacy. Research on the cause of this condition ...more »

Voting

238 votes
Ideate

AoU Research Priorities Use Cases

Submitted by (@drirene)

Could the Precision Medicine Initiative Reduce Social Inequality?

The proposed study would identify microbial communities and metabolic profiles associated with stigmatized conditions such as idiopathic malodor or mental health. Working with systemic malodor/PATM community provides unprecedented opportunities to explore biomarkers of depression, social stress, diabetes, inflammatory diseases, dental, cardiovascular, and digestive health, exposure to antibiotics, lifestyle & dietary ...more »

Voting

219 votes
Ideate

AoU Research Priorities Use Cases

Submitted by

Is a history of localized provoked or generalized vulvodynia associated with lower urinary tract symptoms (LUTS)?

8% of women may experience stigmatizing and debilitating chronic vulvar pain (vulvodynia) by age 40. Recurrent urogenital infections are associated with vulvodynia and women with vulvodynia may be at risk of LUTS. Vulvodynia patients fail to seek care and therefore we propose to ask women to report any period of pain during intercourse, tampon use, or at the time of a pelvic examination that lasted for at least 3 months ...more »

Voting

199 votes
Ideate

AoU Research Priorities Use Cases

Submitted by (@nichd.allofus)

What are the unique factors associated with early onset obesity in different ethnic and racial groups?

This study will focus on women who are pregnant when they enroll, or become pregnant during the study, in order to follow their infants from birth to 8 years of age to determine trajectories of growth over time and identify genomic and epigenomic factors related to development of obesity. Critical to obtaining this information will be the review of Electronic Health Records of providers who have the correct measuring ...more »

Voting

155 votes
Ideate

AoU Research Priorities Use Cases

Submitted by (@nichd.allofus)

What microbiome characteristics of children exposed to antibiotics and different diets influence long-term health outcomes?

Follow a subsample of all infants and children (< 3 years of age) throughout childhood to obtain the following serial assessments: blood tests, medication history, neonatal, infant and childhood health outcomes; physical measurements and laboratory microbiologic evaluations of oral, skin and vaginal specimens. Assessments and measures would be used along with health outcomes to determine associations and develop predictive ...more »

Voting

153 votes
Ideate

AoU Research Priorities Use Cases

Submitted by (@noemie.elhadad)

What are the genetic, epigenetic, and environmental factors of endometriosis, and how can they help us identify its subtypes?

Endometriosis is a systemic condition with a heavy burden on patients. It is estimated that 10% of women in reproductive age have endometriosis, but its etiology is still unknown. While it is accepted that endometriosis is a heterogeneous condition, what the exact subtypes of the disease are is still an open question.

Voting

144 votes
Ideate

AoU Research Priorities Use Cases

Submitted by (@acsm1954)

What is the comparative and independent effectiveness of healthy lifestyle choices in preventing and treating diseases?

Determine the lifestyle strategies and interventions that produce the most gains in prevention and treatment of diseases in a comparative and complementary context with pharmaceutical, surgical, and other approaches. Methods could include data collection through wearable technology, validated self-reports, comparative effectiveness data, medical reimbursement, predictive analytics, and the unique insights from All of ...more »

Voting

139 votes
Ideate

AoU Research Priorities Use Cases

Submitted by (@fimcoalition)

What is the relationship between providing medically tailored meals and the reduction in hospital utilization for ill people?

Goal: Prove that medically tailored home-delivered meals reduce hospital utilization for seriously ill individuals Methods: Randomized control study where the experimental group (seriously ill individuals with ADL limitations recently released from the hospital) receive 21 medically tailored meals per week (including MNT from a RDN for 9 months, while the control group receives SOC the standard of care). Patients will ...more »

Voting

138 votes
Ideate

AoU Research Priorities Use Cases

Submitted by (@acsm1954)

What active and healthy lifestyle interventions will most effectively reduce health disparities and increase health equity?

Intentionally aim to ensure that All of Us insights extend to everyone, particularly regarding lifestyles and improved health for population segments of need and opportunity. Methods could include data collection through wearable technology, validated self-reports, comparative effectiveness data, medical reimbursement, predictive analytics, and the unique insights from All of Us. ACSM applauds this pathway to health innovation. ...more »

Voting

136 votes
Ideate

AoU Research Priorities Use Cases

Submitted by (@nichd.allofus)

What are the long-term effects and risks of opioid use disorder during pregnancy on maternal and child health?

This study will focus on the entire cohort. The goal will be to determine the interaction of genomic, sociodemographic, physiologic and environmental factors for the mother and child impacted by Neonatal Opioid Withdrawal Syndrome (NOWS) and their impact on treatment response, treatment outcome, health outcomes for the mother, and developmental outcomes for the child.

Voting

120 votes
Ideate

AoU Research Priorities Use Cases

Submitted by (@acsm1954)

How can precision medicine be most effectively used to influence lifestyle choices and behaviors, such as physical activity?

A transformative goal would be to use precision medicine to individualize and make far more effective dose-response interventions and prescriptions for physical activity and other health behaviors. Methods could include data collection through wearable technology, validated self-reports, other existing health data, and the unique insights from All of Us, especially related to sources and effects of lifestyle influence. ...more »

Voting

119 votes
Ideate

AoU Research Priorities Use Cases

Submitted by (@acsm1954)

What aspects of the built environment, policies, and programs most effectively influence healthy lifestyle choices?

An improved understanding of the wide-ranging interplay of community design, programs, policies, worksite health, physician counseling, and other factors in influencing health behaviors and lifestyle choices is crucial to improving health outcomes. Methods could include data collection through wearable technology, validated self-reports, medical reimbursement, predictive analytics, and the unique insights from All of ...more »

Voting

119 votes
Ideate