This study will focus on the entire cohort. The goal will be to determine the interaction of genomic, sociodemographic, physiologic and environmental factors for the mother and child impacted by Neonatal Opioid Withdrawal Syndrome (NOWS) and their impact on treatment response, treatment outcome, health outcomes for the mother, and developmental outcomes for the child.

N/A

To study genotype-phenotype correlations, utilize measures targeting the Broader Autism Phenotype: social and communication scales (SRS), Connors Rating Scale for ADHD, ratings of depressive symptoms (PHQ-9), anxiety disorders, & adverse childhood experiences (ACEs) & traumatic life events. Children transitioning to adulthood during the study will have repeat assessment of function and mental health status at a later... more »

Since ultrasounds came into use in the 1970's, autism has been on the rise. Originally used later in pregnancy and now very early in pregnancy. Before it was the norm, it was shown on a program that a drop of water on an ultrasound paddle would disintegrate immediately so the concern was WHAT was it doing to the fetus' brain? A study could have a large group of women NOT have ultrasounds during their pregnancy, and... more »

Goal: Show that a strict, and life-long adherence to a healthy life style retards the aging process, enables you to avoid many common diseases, and allows you to greatly reduce healthcare costs. Method: Invite participants from all over the world to commit to following a healthy life style regimen throughout life. Expected outcomes: Participates age more slowly, have fewer chronic diseases, and spend less on health... more »

Alcohol affects nearly all major diseases. Failing to capture lifetime alcohol exposure will adversely affect the goals of All of Us.

There are better questions about consumption, that should be asked of previous year, typical year and heaviest year.

Questions should be asked about problems due to alcohol, and those should be focused on lifetime.

Additional questions about other drugs should also be included.

To follow yoga practitioners to see if they experience better physical and mental health in the long term. For those with a chronic disease does it contribute positively to symptom management.

A cohort study of pre-teens with high functioning autism, formerly Aspergers, would collect data about pharmacological and behavioral therapies tried and obtain dose and duration of treatments. Survey data from parents would measure functioning and stress tolerance at age 10, 13 and 18.

Collect data on the number of meals eaten per day, the times of those meals, estimated calories in each meal, when people go to sleep, and when people wake up. Then test for the health effects of (a) meal frequency, (b) the daily eating/fasting duration, and (c) the time of day that people eat (e.g., quantified as the mid-point of the eating period or at the 50% mark for caloric consumption during the daytime). You'll... more »

Use standardized questions to examine both normal use of drugs, natural history of use and abuse (when started, how much, efforts to quit, used despite harmful consequences, etc). Most health conditions are influenced by drug use, so not collecting this sort of data compromises the entire project. Must distinguish recreational from compulsive use.

If you offer 100 people $50 today or $60 in two months, some will choose the smaller reward now, others will choose the larger reward later. The way people evaluate current versus future rewards is partially genetic and has broad implications for a variety of health outcomes. We have already published on this paradigm (https://www.nature.com/articles/s41593-017-0032-x) but much more data is needed, ideally in subject... more »

The burden of sudden cardiac death remains high, accounting for over 350,000 deaths in the US annually. The implantable defibrillator remains the major primary prevention modality. However, in order for this important measure to stay sustainable from a health costs perspective, the criteria for selecting candidates most likely to benefit need to be improved significantly. It will be important to identify all use cases... more »

Collect and store biomarkers on everyone (hair, blood, urine, saliva, microbiome samples, etc.) and pursue specific questions as become relevant using an efficient case-cohort study design. Given the temporal variability in some biomarker values, it is important to collect multiple samples for at least subsets of the population, and questionnaire data on everyone, to help model variables that show temporal variability.... more »

A brief simple non denominational questionnaire during medical encounters about patients spirituality and following major health outcomes over a 5 year period.

Goal: Survey patients with autoimmune diseases for information on occupational and other life style exposures to factors associated with autoimmunity (smoking, silica dust, solvents, etc). Build data bases containing clinical parameters, blood tests, and exposure data to help identify putative diagnostic criteria. Compare with patients having idiopathic autoimmunity (i.e. lacking known risk exposures)