AoU Research Priorities Use Cases

See others’ ideas.

Below are the research questions others have already entered. IdeaScale is temporarily closed, but you can read what has been submitted so far. When re-opened, you can leave a comment or vote for the ideas you like. At that time, you'll also be able to submit your own idea.

When you are ready to submit your own idea after IdeaScale is re-opened, click the "Submit New Idea" button in the top right corner. Moderators from our team will review your submission and then add it to the rest of the submitted research questions.

To review the All of Us Research Program's Policy on Posting in IdeaScale, please click here.
(@nichd.allofus)

AoU Research Priorities Use Cases

What are the long-term effects and risks of opioid use disorder during pregnancy on maternal and child health?

This study will focus on the entire cohort. The goal will be to determine the interaction of genomic, sociodemographic, physiologic and environmental factors for the mother and child impacted by Neonatal Opioid Withdrawal Syndrome (NOWS) and their impact on treatment response, treatment outcome, health outcomes for the mother, and developmental outcomes for the child.

Voting

120 votes
Ideate
(@nichd.allofus)

AoU Research Priorities Use Cases

What are the genetic and environmental risk factors that contribute to the broader autism phenotype in adolescents and adults?

To study genotype-phenotype correlations, utilize measures targeting the Broader Autism Phenotype: social and communication scales (SRS), Connors Rating Scale for ADHD, ratings of depressive symptoms (PHQ-9), anxiety disorders, & adverse childhood experiences (ACEs) & traumatic life events. Children transitioning to adulthood during the study will have repeat assessment of function and mental health status at a later... more »

Voting

42 votes
Ideate
(@tinykrukowskifrye.home)

AoU Research Priorities Use Cases

Could ultrasounds on pregnant women be the cause of the rise of autism in children over the years?

Since ultrasounds came into use in the 1970's, autism has been on the rise. Originally used later in pregnancy and now very early in pregnancy. Before it was the norm, it was shown on a program that a drop of water on an ultrasound paddle would disintegrate immediately so the concern was WHAT was it doing to the fetus' brain? A study could have a large group of women NOT have ultrasounds during their pregnancy, and... more »

Voting

28 votes
Ideate
(@karen.montefiori)

AoU Research Priorities Use Cases

How does a life-long adherence to healthy life style habits affect the aging process?

Goal: Show that a strict, and life-long adherence to a healthy life style retards the aging process, enables you to avoid many common diseases, and allows you to greatly reduce healthcare costs. Method: Invite participants from all over the world to commit to following a healthy life style regimen throughout life. Expected outcomes: Participates age more slowly, have fewer chronic diseases, and spend less on health... more »

Voting

33 votes
Ideate
(@edenberg)

AoU Research Priorities Use Cases

The effects of alcohol (and other drug) consumption on major somatic diseases and psychiatric disorders and their treatments.

Alcohol affects nearly all major diseases. Failing to capture lifetime alcohol exposure will adversely affect the goals of All of Us.

There are better questions about consumption, that should be asked of previous year, typical year and heaviest year.

Questions should be asked about problems due to alcohol, and those should be focused on lifetime.

Additional questions about other drugs should also be included.

Voting

61 votes
Ideate
(@scherrjf)

AoU Research Priorities Use Cases

What treatments are effective in reducing anxiety and increasing stress tolerance in high-functioning, children with autism

A cohort study of pre-teens with high functioning autism, formerly Aspergers, would collect data about pharmacological and behavioral therapies tried and obtain dose and duration of treatments. Survey data from parents would measure functioning and stress tolerance at age 10, 13 and 18.

Voting

85 votes
Ideate
(@cpeterso)

AoU Research Priorities Use Cases

How does meal timing affect health?

Collect data on the number of meals eaten per day, the times of those meals, estimated calories in each meal, when people go to sleep, and when people wake up. Then test for the health effects of (a) meal frequency, (b) the daily eating/fasting duration, and (c) the time of day that people eat (e.g., quantified as the mid-point of the eating period or at the 50% mark for caloric consumption during the daytime). You'll... more »

Voting

50 votes
Ideate
(@aap.ucsd.edu)

AoU Research Priorities Use Cases

Conduct research to identify genetic factors that influence recreational use and abuse of alcohol and other drugs of abuse

Use standardized questions to examine both normal use of drugs, natural history of use and abuse (when started, how much, efforts to quit, used despite harmful consequences, etc). Most health conditions are influenced by drug use, so not collecting this sort of data compromises the entire project. Must distinguish recreational from compulsive use.

Voting

38 votes
Ideate
(@aap.ucsd.edu)

AoU Research Priorities Use Cases

How do people evaluate current rewards relative to future (delayed) rewards

If you offer 100 people $50 today or $60 in two months, some will choose the smaller reward now, others will choose the larger reward later. The way people evaluate current versus future rewards is partially genetic and has broad implications for a variety of health outcomes. We have already published on this paradigm (https://www.nature.com/articles/s41593-017-0032-x) but much more data is needed, ideally in subject... more »

Voting

28 votes
Ideate
(@suddencardiacdeath)

AoU Research Priorities Use Cases

Reduce the burden of sudden cardiac death by identifying individuals who benefit the most from the implantable defibrillator.

The burden of sudden cardiac death remains high, accounting for over 350,000 deaths in the US annually. The implantable defibrillator remains the major primary prevention modality. However, in order for this important measure to stay sustainable from a health costs perspective, the criteria for selecting candidates most likely to benefit need to be improved significantly. It will be important to identify all use cases... more »

Voting

35 votes
Ideate
(@jaymie.meliker)

AoU Research Priorities Use Cases

Integrate the exposome, epigenome, genome, and microbiome to study many disease states.

Collect and store biomarkers on everyone (hair, blood, urine, saliva, microbiome samples, etc.) and pursue specific questions as become relevant using an efficient case-cohort study design. Given the temporal variability in some biomarker values, it is important to collect multiple samples for at least subsets of the population, and questionnaire data on everyone, to help model variables that show temporal variability.... more »

Voting

37 votes
Ideate
(@mpollard)

AoU Research Priorities Use Cases

Criteria for Environmental Associated Autoimmune Diseases

Goal: Survey patients with autoimmune diseases for information on occupational and other life style exposures to factors associated with autoimmunity (smoking, silica dust, solvents, etc). Build data bases containing clinical parameters, blood tests, and exposure data to help identify putative diagnostic criteria. Compare with patients having idiopathic autoimmunity (i.e. lacking known risk exposures)

Voting

55 votes
Ideate