(@measurenutrition) kudos icon +

AoU Research Priorities Use Cases

What is the contribution of dietary patterns and nutritional status to chronic disease susceptibility and prevention?

The top four causes of deaths in the U.S. are diet related and many other troublesome diseases are affected by diet, It will be important therefore to capture nutritional status, food environment, and repeated 24h (ASA24s) dietary intakes along with measures that can validate dietary measures of public policy interest including added sugar, energy, protein, sodium, iron, vitamins, dietary supplements, potassium, fruits... more »

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67 votes
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(@carterrob) kudos icon +

AoU Research Priorities Use Cases

How do autoimmune diseases start?

Many autoimmune diseases are characterized by the presence of autoantibodies. These may be present long before disease starts, but what triggers the transition from autoimmunity (the presence of the antibodies) to disease is unknown, but is likely to include both environmental exposures and genetic susceptibility. What are the risk factors for the transition to disease? Are these modifiable? In which patients is the risk... more »

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66 votes
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(@annabkim) kudos icon +

AoU Research Priorities Use Cases

Identify if formula use in babies resulted in obesity in those individuals in adulthood

Background: I have heard of a theory that the abundance of food/nutrition in infant stages alters how the individual metabolizes food later in life. As a mother, I have observed my babies working harder when nursing compared to when being bottle fed. This may indicate formula fed babies drink more (abundance) and that may change how they eat, the volume and storage of fat.
Trace both sets of individuals (obese vs healthy... more »

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64 votes
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(@edenberg) kudos icon +

AoU Research Priorities Use Cases

The effects of alcohol (and other drug) consumption on major somatic diseases and psychiatric disorders and their treatments.

Alcohol affects nearly all major diseases. Failing to capture lifetime alcohol exposure will adversely affect the goals of All of Us.

There are better questions about consumption, that should be asked of previous year, typical year and heaviest year.

Questions should be asked about problems due to alcohol, and those should be focused on lifetime.

Additional questions about other drugs should also be included.

Voting

61 votes
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(@nfschor) kudos icon +

AoU Research Priorities Use Cases

Are there patient characteristics that predict resilience to and coping strategies and treatments chosen for recurrent pain?

Identify subsets of All of Us participants with chronic pain of various types. Administer questionnaire that asks in general about coping mechanisms, self-perceived pain tolerance, interference of pain disorder with function, child and adult exposures to adverse life experiences, history of depression/PTSD, drivers of decision of whether or not to treat an episode of pain, use of pharmacological therapies, use of non-pharmacological... more »

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59 votes
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(@chriskelly151) kudos icon +

AoU Research Priorities Use Cases

How can you help people who have anosmia?

Anosmia, the loss of smell, affects approximately 5% of the population and can blight the lives of sufferers. The consequences to well being of those with this condition can be severe and include depression, anxiety, aggression, feelings of isolation as well as weight gain/weight loss. Within this group are people with parosmia, a condition where odors are so distorted that food becomes a nauseating ordeal. We need more... more »

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58 votes
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(@acaple07) kudos icon +

AoU Research Priorities Use Cases

Could regular screening for postpartum for up to a year after birth decrease postpartum depression?

I would select women who has just given birth or have children ranging from 3 months, 6 months, and 9 months to get a postpartum screening done every three months to see if they have any signs of postpartum. The outcome is to see what and how the mother is feeling in the different milestones of the child's life as well as their own. What effects does it have on both the mother and the child

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57 votes
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(@jtrachtman) kudos icon +

AoU Research Priorities Use Cases

Identify treatments for the loss of smell (anosmia)

I am a lay person and I cannot provide detail on study design. However, I am aware that there are millions of individuals world-wide who suffer from loss of smell (anosmia) and who feel socially isolated and fearful of dangers that the olfactory system helps to warn against. In addition, many people who are anosmic do not enjoy eating and are therefore not necessarily getting a nutritionally balanced diet. This could... more »

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56 votes
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(@mpollard) kudos icon +

AoU Research Priorities Use Cases

Criteria for Environmental Associated Autoimmune Diseases

Goal: Survey patients with autoimmune diseases for information on occupational and other life style exposures to factors associated with autoimmunity (smoking, silica dust, solvents, etc). Build data bases containing clinical parameters, blood tests, and exposure data to help identify putative diagnostic criteria. Compare with patients having idiopathic autoimmunity (i.e. lacking known risk exposures)

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55 votes
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(@zenknutrition) kudos icon +

AoU Research Priorities Use Cases

How do local, regional, state, and national retail food environments and policies affect diet and health?

Obesity and poor diet are threats to population health. The food environment and related policies may be major contributors. Longitudinal measures of food purchasing, diet, and health can be linked to environmental/policy data (eg community gardens, changes in convenience store offerings, fast food moratoriums, menu labeling, food taxes/subsidies), and used to identify health effects. Results can help prioritize multilevel... more »

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55 votes
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(@jatkinso) kudos icon +

AoU Research Priorities Use Cases

What genetic factors and environmental factors are associated with dental caries?

Dental caries affects 90% of US adults and is more severe in underserved populations. Caries is caused by a complex biofilm and severity is influenced by dietary intake of sugars. Recent studies have identified caries-susceptibility alleles, some of which may be modified by fluoride use. However, more studies are needed in diverse populations. Understanding genetic factors influencing dental caries may improve caries... more »

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54 votes
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(@robertjohnson.rlj) kudos icon +

AoU Research Priorities Use Cases

What social impact does children-health play in the developmental stage in while in primary school.

I would design a seven-year-long protocol study that would observe children social developmental stages from various demographics from the pre-school to the fifth-grade. As we look at their food-nutrient intake; family social structure-dynamics environment; social interaction; extracurricular activities; and educational resources in order to see how to reduce disadvantage youth while increase child readiness.

Voting

54 votes
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(@hakunamatata414) kudos icon +

AoU Research Priorities Use Cases

How can a loss of the sense of smell (acquired anosmia) be reversed?

From www.monell.org:

Monell’s initial targeted anosmia research project takes advantage of 1) the unique ability of olfactory receptor cells to regenerate from specialized stem cells across a person’s lifetime, and 2) Monell’s pioneering development of biopsy techniques that enable us to harvest and study living human olfactory tissue.

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52 votes
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