AoU Research Priorities Use Cases

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Below are the research questions others have already entered. IdeaScale is temporarily closed, but you can read what has been submitted so far. When re-opened, you can leave a comment or vote for the ideas you like. At that time, you'll also be able to submit your own idea.

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(@ermueller)

AoU Research Priorities Use Cases

What is the impact of fluid intake on health?

There is a fluid intake range that is healthy. Below this level predisposes to urinary tract infections, urinary stone formation, changes in the gut and urinary micro biome, and results in generalized symptoms of well-being. Fluid intake above a healthy threshold predisposes to lower urinary tract symptoms, sleep interruptions and may affect symptoms of well-being.

Voting

48 votes
Ideate
(@drirene)

AoU Research Priorities Use Cases

Could the Precision Medicine Initiative Reduce Social Inequality?

The proposed study would identify microbial communities and metabolic profiles associated with stigmatized conditions such as idiopathic malodor or mental health. Working with systemic malodor/PATM community provides unprecedented opportunities to explore biomarkers of depression, social stress, diabetes, inflammatory diseases, dental, cardiovascular, and digestive health, exposure to antibiotics, lifestyle & dietary... more »

Voting

219 votes
Ideate
(@annabkim)

AoU Research Priorities Use Cases

Identify if formula use in babies resulted in obesity in those individuals in adulthood

Background: I have heard of a theory that the abundance of food/nutrition in infant stages alters how the individual metabolizes food later in life. As a mother, I have observed my babies working harder when nursing compared to when being bottle fed. This may indicate formula fed babies drink more (abundance) and that may change how they eat, the volume and storage of fat. Trace both sets of individuals (obese vs healthy... more »

Voting

64 votes
Ideate
(@sergio)

AoU Research Priorities Use Cases

Which observations of daily living are more effective in monitoring and improving a patient's overall well-being?

Observations of daily living (ODL) are easily collected by patients or their families. They are dynamic, patient-generated data that improve decisions regarding health and well-being, for example mood or sleep patterns. When integrated with medical data, ODLs help provide a holistic view of the patient. Other benefits include significantly expanding the time window and detail in which a patient recalls events, as... more »

Voting

29 votes
Ideate
(@qtnguyen)

AoU Research Priorities Use Cases

What neighborhood conditions promote health?

This project would examine contextual factors that may influence the health outcomes of individuals. Contextual factors include social environment factors (such as social cohesion, crime) and built environment factors (green space, mixed land use, access to healthy food and clinical services). These factors can help or hinder individuals from achieving or maintaining health. Outcomes of interest include obesity, diabetes,... more »

Voting

45 votes
Ideate
(@reginald)

AoU Research Priorities Use Cases

Would same-gender care increase the utilization of health care by men in the US?

A study to produce evidence that men would increase their utilization of health care, if same-gender care was offered to them (especially for intimate care)? If a male attendant was available, would more men seek help? Could health care be made more accessible (because more men would seek help, especially those with cultural sensitivities) and equitable (because men would be afforded the same option as women- i.e. women... more »

Voting

24 votes
Ideate
(@c.stillwell94)

AoU Research Priorities Use Cases

Are individuals with Down’s Syndrome more likely to be overweight or obese? If so, why? What can we do to help them? And how doe

Within the US there are numerous people with Down’s Syndrome. Most are overweight or obese. This research study would include finding out why individuals with Down’s are overweight and if it is because of a predisposing factor that cannot be controlled such as genetics or a modification made by the chromosomal editing. It will also look at, what ways we can help those individuals with weight needs. Discovering how individuals... more »

Voting

43 votes
Ideate
(@susanpl13)

AoU Research Priorities Use Cases

Does insufficient, disordered, or mistimed sleep cause physical/mental illness?

The CDC calls insufficient sleep a "public health problem." But sleep & circadian rhythms are oft-ignored—even derided--aspects of health. When you ask subjects about lifestyle, don't stop @ diet/exercise. Ask about sleep. When you ask about sleep, don't stop @ length/quality. Ask about circadian timing: when ppl sleep. Is timing dictated by their body clock *or* work/family demands? AOU is an unprecedented opp to... more »

Voting

80 votes
Ideate
(@susanpl13)

AoU Research Priorities Use Cases

What causes circadian rhythm disorders (CRDs): delayed sleep phase disorder; non-24-hr sleep-wake disorder; advanced phase?

Ppl w/ CRDs are told, "Try harder to sleep/wake when society does." But CRD ppl are held hostage by body clocks that defy control. CRDs derail education, employment, relationships, parenting, life. AOU is about inclusivity & less-common conditions. What causes CRDs? Genetic mutations; light over/undersensitivity; faulty eye ipRGCs; impaired melatonin production/metabolism; faulty homeostatic sleep drive; environmental... more »

Voting

46 votes
Ideate
(@holly.nicastro)

AoU Research Priorities Use Cases

What factors predict successful long-term weight loss maintenance?

>60% of U.S. adults are classified as overweight/obese. Treatments to promote long-term weight loss (e.g. behavioral, pharmacological, surgical) are often not successful and result in high variability across individuals. Measurement of potential predictors from multiple domains (behavioral, biological, environmental, and psychosocial) can help identify the factors that best predict success in response to intentional weight... more »

Voting

73 votes
Ideate
(@nfschor)

AoU Research Priorities Use Cases

Are there patient characteristics that predict resilience to and coping strategies and treatments chosen for recurrent pain?

Identify subsets of All of Us participants with chronic pain of various types. Administer questionnaire that asks in general about coping mechanisms, self-perceived pain tolerance, interference of pain disorder with function, child and adult exposures to adverse life experiences, history of depression/PTSD, drivers of decision of whether or not to treat an episode of pain, use of pharmacological therapies, use of non-pharmacological... more »

Voting

59 votes
Ideate
(@epidermoid1)

AoU Research Priorities Use Cases

Is there a genetic or environmental component to to the neural tube defect of epidermoid brain tumors or cysts?

Look for genetic component to the epidermoid brain tumor that forms in the 3rd to 5th week of pregnancy,a neural tube defect. An environmental study to study maternal/paternal health or environment contributes to neural tube defects and epidermoid cysts that causes much disability. Could any pharmaceutical agents shrink these tumors. Medical treatments to treat these tumors as surgery is the only treatment.. They are... more »

Voting

43 votes
Ideate
(@mpwhitmire)

AoU Research Priorities Use Cases

What social determinants & health/functional factors increase the risk of malnutrition for older adults living in the community?

It is important that the All of Us database includes a range of nutrition-related measures which are used to help identify malnutrition risk. Additional measures of malnutrition-related characteristics are important for malnutrition diagnosis. Validated screening tools such as the Malnutrition Screening Tool (MST) could be used regularly to collect this data, as well as linked surveys to capture demographic information... more »

Voting

75 votes
Ideate
(@robertjohnson.rlj)

AoU Research Priorities Use Cases

What social impact does children-health play in the developmental stage in while in primary school.

I would design a seven-year-long protocol study that would observe children social developmental stages from various demographics from the pre-school to the fifth-grade. As we look at their food-nutrient intake; family social structure-dynamics environment; social interaction; extracurricular activities; and educational resources in order to see how to reduce disadvantage youth while increase child readiness.

Voting

54 votes
Ideate
(@lcaler)

AoU Research Priorities Use Cases

How can we better identify and assess environmental and genetic/physiological risk factors that lead to child/teen stress?

There is tremendous pressure kids are exposed to. This results in an unusual number of children and teen age kids suffering from stress and depression, leading in some cases to devastating consequences. A study that could address to what level there are genetic predispositions to stress and depression and how it intersects with modern pressures and that will involve school, children and parents as cohorts, this could... more »

Voting

107 votes
Ideate