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Gestational diabetes prevalence is higher among Asian Indians, Filipinos, Southeast Asians, and Chinese compared to White, Black, and Hispanic parturients despite the absence of preconceptional obesity. Dissecting the etiology of elevated GDM risk in these Asian-American subgroups, and evaluating effective interventions (other than weight management) to prevent GDM and reduce future risk of type 2 diabetes are urgently ...more »
Obesity prevalence among Samoan Americans, including Samoan children in the US mainland, are higher compared to other ethnic groups. A genetic variation promoting fat storage was observed among Samoans, but effective interventions to reduce the risk of obesity-related health outcomes among Samoans and perhaps other Pacific Islanders and Native Hawaiians with this variant require development and evaluation.
Asian-Americans accumulate excess visceral adipose tissue (VAT) despite the absence of general obesity. Chinese, Filipino and South Asians in the US have more VAT compared to African-Americans. The determinants of excess VAT accumulation in normal weight adults are unclear, and effective interventions to reduce excess VAT accumulation in normal weight Asian-Americans are urgently needed to reduce adverse metabolic health ...more »
Asian Americans have the highest prevalence (51%) of undiagnosed type 2 diabetes (T2D), and half of Asian-Americans and Native Hawaiians with newly diagnosed T2D have isolated post-challenge hyperglycemia (iPCH). They might remain undiagnosed or experience delayed T2D if screening practices are limited to glycosylated hemoglobin and fasting plasma glucose measures. Identification of novel biomarkers to identify individuals ...more »